Seroatlas · Human Serome Atlas

FSD1

Fibronectin type III and SPRY domain-containing protein 1

Also known as: FSD1_HUMAN, MGC3213, MIR1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BTV5
Gene
FSD1
Ensembl
ENSG00000105255
Chromosome
19
Canonical length
496 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a centrosome associated protein that is characterized by an N-terminal coiled-coil region downstream of B-box (BBC) domain, a central fibronectin type III domain, and a C-terminal repeats in splA and RyR (SPRY) domain. The encoded protein associates with a subset of microtubules and may be involved in the stability and organization of microtubules during cytokinesis. [provided by RefSeq, Apr 2009]

Canonical amino-acid sequenceUniProt

496 residues, UniProt reviewed canonical sequence.

>Q9BTV5|FSD1
     1  MEEQREALRK IIKTLAVKNE EIQSFIYSLK QMLLNVEANS AKVQEDLEAE FQSLFSLLEE
    61  LKEGMLMKIK QDRASRTYEL QNQLAACTRA LESSEELLET ANQTLQAMDS EDFPQAAKQI
   121  KDGVTMAPAF RLSLKAKVSD NMSHLMVDFA QERQMLQALK FLPVPSAPVI DLAESLVADN
   181  CVTLVWRMPD EDSKIDHYVL EYRRTNFEGP PRLKEDQPWM VIEGIRQTEY TLTGLKFDMK
   241  YMNFRVKACN KAVAGEFSEP VTLETPAFMF RLDASTSHQN LRVDDLSVEW DAMGGKVQDI
   301  KAREKDGKGR TASPINSPAR GTPSPKRMPS GRGGRDRFTA ESYTVLGDTL IDGGEHYWEV
   361  RYEPDSKAFG VGVAYRSLGR FEQLGKTAAS WCLHVNNWLQ VSFTAKHANK VKVLDAPVPD
   421  CLGVHCDFHQ GLLSFYNART KQVLHTFKTR FTQPLLPAFT VWCGSFQVTT GLQVPSAVRC
   481  LQKRGSATSS SNTSLT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FSD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 35 nTPM
  • hippocampal formation: 24 nTPM
  • hypothalamus: 22 nTPM
  • amygdala: 21 nTPM
  • cerebellum: 20 nTPM
  • midbrain: 15 nTPM

Single-cell type

  • undifferentiated spermatogonia: 48 nCPM
  • brain excitatory neurons: 33 nCPM
  • other brain neurons: 31 nCPM
  • brain inhibitory neurons: 27 nCPM
  • innate lymphoid cells: 27 nCPM
  • nk-cells: 25 nCPM

Immune cell

  • NK-cell: 5.4 nTPM
  • MAIT T-cell: 3.6 nTPM
  • plasmacytoid DC: 1.4 nTPM
  • naive CD4 T-cell: 0.7 nTPM
  • total PBMC: 0.7 nTPM
  • gdT-cell: 0.5 nTPM

Brain region

  • pons: 30 nTPM
  • thalamus: 30 nTPM
  • cerebral cortex: 29 nTPM
  • hippocampal formation: 26 nTPM
  • medulla oblongata: 23 nTPM
  • hypothalamus: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.47
gnomAD pLI
0.25
gnomAD missense Z
1.24
DepMap mean gene effect
-0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FSD1 as an antibody target. Whether an autoantibody or antibody against FSD1 could matter depends on whether native FSD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FSD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FSD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FSD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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