Seroatlas · Human Serome Atlas

TRIM5

Tripartite motif-containing protein 5

Also known as: RNF88, TRIM5_HUMAN, TRIM5alpha

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9C035
Gene
TRIM5
Ensembl
ENSG00000132256
Chromosome
11
Canonical length
493 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Cytosol
Quaternary structure
Homotrimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2009]

Canonical amino-acid sequenceUniProt

493 residues, UniProt reviewed canonical sequence.

>Q9C035|TRIM5
     1  MASGILVNVK EEVTCPICLE LLTQPLSLDC GHSFCQACLT ANHKKSMLDK GESSCPVCRI
    61  SYQPENIRPN RHVANIVEKL REVKLSPEGQ KVDHCARHGE KLLLFCQEDG KVICWLCERS
   121  QEHRGHHTFL TEEVAREYQV KLQAALEMLR QKQQEAEELE ADIREEKASW KTQIQYDKTN
   181  VLADFEQLRD ILDWEESNEL QNLEKEEEDI LKSLTNSETE MVQQTQSLRE LISDLEHRLQ
   241  GSVMELLQGV DGVIKRTENV TLKKPETFPK NQRRVFRAPD LKGMLEVFRE LTDVRRYWVD
   301  VTVAPNNISC AVISEDKRQV SSPKPQIIYG ARGTRYQTFV NFNYCTGILG SQSITSGKHY
   361  WEVDVSKKTA WILGVCAGFQ PDAMCNIEKN ENYQPKYGYW VIGLEEGVKC SAFQDSSFHT
   421  PSVPFIVPLS VIICPDRVGV FLDYEACTVS FFNITNHGFL IYKFSHCSFS QPVFPYLNPR
   481  KCGVPMTLCS PSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
20 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 20 nTPM
  • liver: 18 nTPM
  • salivary gland: 18 nTPM
  • thymus: 14 nTPM
  • smooth muscle: 13 nTPM
  • spleen: 13 nTPM

Single-cell type

  • hematopoietic stem cells: 413 nCPM
  • fibro-adipogenic progenitors: 120 nCPM
  • plasma cells: 99 nCPM
  • syncytiotrophoblasts: 90 nCPM
  • undifferentiated spermatogonia: 87 nCPM
  • epicardial cells: 86 nCPM

Immune cell

  • basophil: 11 nTPM
  • neutrophil: 9.7 nTPM
  • eosinophil: 9.6 nTPM
  • myeloid DC: 9.5 nTPM
  • plasmacytoid DC: 9.5 nTPM
  • non-classical monocyte: 9.3 nTPM

Brain region

  • choroid plexus: 15 nTPM
  • medulla oblongata: 11 nTPM
  • thalamus: 9.7 nTPM
  • midbrain: 9.5 nTPM
  • hypothalamus: 8.7 nTPM
  • pons: 8.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.01
gnomAD pLI
0
gnomAD missense Z
-0.47
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIM5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM5 as an antibody target. Whether an autoantibody or antibody against TRIM5 could matter depends on whether native TRIM5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRIM5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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