Seroatlas · Human Serome Atlas

TRIM58

E3 ubiquitin-protein ligase TRIM58

Also known as: BIA2, TRI58_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NG06
Gene: TRIM58
Ensembl: ENSG00000162722
Chromosome: 1
Canonical length: 486 aa
Protein class: Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

486 residues, UniProt reviewed canonical sequence.

>Q8NG06|TRIM58
     1  MAWAPPGERL REDARCPVCL DFLQEPVSVD CGHSFCLRCI SEFCEKSDGA QGGVYACPQC
    61  RGPFRPSGFR PNRQLAGLVE SVRRLGLGAG PGARRCARHG EDLSRFCEED EAALCWVCDA
   121  GPEHRTHRTA PLQEAAGSYQ VKLQMALELM RKELEDALTQ EANVGKKTVI WKEKVEMQRQ
   181  RFRLEFEKHR GFLAQEEQRQ LRRLEAEERA TLQRLRESKS RLVQQSKALK ELADELQERC
   241  QRPALGLLEG VRGVLSRSKA VTRLEAENIP MELKTACCIP GRRELLRKFQ VDVKLDPATA
   301  HPSLLLTADL RSVQDGEPWR DVPNNPERFD TWPCILGLQS FSSGRHYWEV LVGEGAEWGL
   361  GVCQDTLPRK GETTPSPENG VWALWLLKGN EYMVLASPSV PLLQLESPRC IGIFLDYEAG
   421  EISFYNVTDG SYIYTFNQLF SGLLRPYFFI CDATPLILPP TTIAGSGNWA SRDHLDPASD
   481  VRDDHL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM58 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 30 nTPM
thyroid gland: 14 nTPM
placenta: 5.4 nTPM
spleen: 3.8 nTPM
testis: 2.5 nTPM
hypothalamus: 1.8 nTPM

Single-cell type

platelets: 1,455 nCPM
erythrocytes: 478 nCPM
megakaryocytes: 124 nCPM
hematopoietic stem cells: 79 nCPM
megakaryocyte-erythroid progenitors: 74 nCPM
erythrocyte progenitors: 63 nCPM

Immune cell

memory B-cell: 0.8 nTPM
basophil: 0.7 nTPM
neutrophil: 0.6 nTPM
total PBMC: 0.6 nTPM
eosinophil: 0.3 nTPM
NK-cell: 0.3 nTPM

Brain region

pons: 11 nTPM
midbrain: 11 nTPM
hypothalamus: 8.2 nTPM
medulla oblongata: 8.1 nTPM
thalamus: 5.3 nTPM
spinal cord: 4.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.57
gnomAD pLI: 0
gnomAD missense Z: 0.42
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

innate immune response
protein autoubiquitination
protein polyubiquitination
regulation of gene expression
ubiquitin-dependent protein catabolic process
positive regulation of erythrocyte enucleation
regulation of nuclear migration along microtubule

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

B-box-type zinc finger
Zinc finger, RING-type
B30.2/SPRY domain
SPRY domain
Butyrophylin-like, SPRY domain
SPRY-associated
Zinc finger, RING/FYVE/PHD-type
Concanavalin A-like lectin/glucanase domain superfamily
Zinc finger, RING-type, conserved site
B30.2/SPRY domain superfamily
Tripartite motif-containing
SPRY domain
B-box zinc finger
SPRY-associated domain
zinc finger of C3HC4-type, RING
E3 ubiquitin-protein ligase TRIM58, PRY/SPRY domain
E3 ubiquitin-protein ligase TRIM58, RING finger, HC subclass

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM58 as an antibody target. Whether an autoantibody or antibody against TRIM58 could matter depends on whether native TRIM58 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM58 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM58 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...