Seroatlas · Human Serome Atlas

FSD2

Fibronectin type III and SPRY domain-containing protein 2

Also known as: FSD2_HUMAN, RP11-127F21, SPRYD1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A1L4K1
Gene
FSD2
Ensembl
ENSG00000186628
Chromosome
15
Canonical length
749 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a protein that belongs to the FN3/SPRY family of proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

749 residues, UniProt reviewed canonical sequence.

>A1L4K1|FSD2
     1  MEEESGEELG LDRSTPKDFH FYHMDLYDSE DRLHLFPEEN TRMRKVVQAE MANESRGAGD
    61  GKAQRDLQEE VDELVHLYGL EDDHELGDEF VDENIPRTGV SEYPPYMMKR RDPAREQRDW
   121  RLSGEAAEAE DLGFGGWGSA GQCQDLREAY RYTHGRASEE YECYVIPEEE DEEEAADVFC
   181  VTCKTPIRAF QKVFDEHKEH EVIPLNEALE SAKDEIHKNM YKLEKQIIEM ENFANHLEEV
   241  FITVEENFGK QEQNFESHYN EILETLAQKY EEKIQALGEK KKEKLEALYG QLVSCGENLD
   301  TCKELMETIE EMCHEEKVDF IKDAVAMADR LGKFLKTKTD VEISAQPEFE DQTLDFSDVE
   361  QLMGSINTIP APSAPVINPQ VPNSATGSSV RVCWSLYSDD TVESYQLSYR PVQDSSPGTD
   421  QAEFTVTVKE TYCSVTNLVP NTQYEFWVTA HNRAGPSPSS ERAVYMTAPS PPIIKTKEIR
   481  SCEEAVLICW ESGNLNPVDS YTVELTQAES PEASGVTESV VGIPTCESVV QLQPGRSYII
   541  YVRALNMGGP SVRSEPATVH TIGSYFRLNK DTCHPWLTIS EDGLTAVRSE RRTPARELSP
   601  SDTHFTRCVA VMGNLIPVRG HHYWEVEVDE HLDYRVGVAF ADVRKQEDLG ANCLSWCMRH
   661  TFASSRHKYE FLHNRTTPDI RITVPPKKIG ILLDYEHSKL SFFNVDLSQH LYTFSCQLHE
   721  FVHPCFSLEK PGCLKVHNGI SMPKHVTFY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FSD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
145 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 145 nTPM
  • heart muscle: 49 nTPM
  • tongue: 41 nTPM
  • retina: 2.2 nTPM
  • esophagus: 1.9 nTPM
  • skin: 1.4 nTPM

Single-cell type

  • myonuclei: 801 nCPM
  • cardiomyocytes: 163 nCPM
  • thymic myoid cells: 71 nCPM
  • adipocytes: 24 nCPM
  • retinal ganglion cells: 23 nCPM
  • myosatellite cells: 22 nCPM

Immune cell

  • basophil: 0.4 nTPM
  • naive CD4 T-cell: 0.2 nTPM
  • classical monocyte: 0.1 nTPM
  • eosinophil: 0.1 nTPM
  • gdT-cell: 0.1 nTPM
  • MAIT T-cell: 0.1 nTPM

Brain region

  • cerebellum: 4.4 nTPM
  • white matter: 4.2 nTPM
  • hypothalamus: 3.9 nTPM
  • cerebral cortex: 3.7 nTPM
  • hippocampal formation: 3.4 nTPM
  • basal ganglia: 3.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.27
gnomAD pLI
0
gnomAD missense Z
0.25
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FSD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FSD2 as an antibody target. Whether an autoantibody or antibody against FSD2 could matter depends on whether native FSD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FSD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FSD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FSD2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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