TRIM15

Protein identityUniProt · HPA

UniProt accession

Q9C019

Gene

TRIM15

Ensembl

ENSG00000204610

Chromosome

6

Canonical length

465 aa

Protein class

Predicted intracellular proteins

Subcellular location

Centriolar satellite,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

465 residues, UniProt reviewed canonical sequence.

>Q9C019|TRIM15
     1  MPATPSLKVV HELPACTLCA GPLEDAVTIP CGHTFCRLCL PALSQMGAQS SGKILLCPLC
    61  QEEEQAETPM APVPLGPLGE TYCEEHGEKI YFFCENDAEF LCVFCREGPT HQAHTVGFLD
   121  EAIQPYRDRL RSRLEALSTE RDEIEDVKCQ EDQKLQVLLT QIESKKHQVE TAFERLQQEL
   181  EQQRCLLLAR LRELEQQIWK ERDEYITKVS EEVTRLGAQV KELEEKCQQP ASELLQDVRV
   241  NQSRCEMKTF VSPEAISPDL VKKIRDFHRK ILTLPEMMRM FSENLAHHLE IDSGVITLDP
   301  QTASRSLVLS EDRKSVRYTR QKKSLPDSPL RFDGLPAVLG FPGFSSGRHR WQVDLQLGDG
   361  GGCTVGVAGE GVRRKGEMGL SAEDGVWAVI ISHQQCWAST SPGTDLPLSE IPRGVRVALD
   421  YEAGQVTLHN AQTQEPIFTF TASFSGKVFP FFAVWKKGSC LTLKG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.38

Highest tissue expression

16 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.31

gnomAD pLI

0

gnomAD missense Z

0.41

DepMap mean gene effect

-0.04

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• innate immune response
• mesodermal cell fate determination
• negative regulation of intracellular transport of viral material
• negative regulation of non-canonical NF-kappaB signal transduction
• positive regulation of RIG-I signaling pathway
• positive regulation of type I interferon production
• suppression of viral release by host

Molecular functions

• molecular sequestering activity
• transcription coactivator activity
• ubiquitin protein ligase activity
• zinc ion binding

Cellular components

• cytoplasm
• focal adhesion
• nucleus

Protein domainsUniProt · Pfam · InterPro

• B-box-type zinc finger
• Zinc finger, RING-type
• B30.2/SPRY domain
• SPRY domain
• Butyrophylin-like, SPRY domain
• SPRY-associated
• Zinc finger, RING/FYVE/PHD-type
• Concanavalin A-like lectin/glucanase domain superfamily
• Zinc finger, RING-type, conserved site
• Zinc finger, C3HC4 RING-type
• B30.2/SPRY domain superfamily
• Tripartite motif-containing
• Zinc finger, C3HC4 type (RING finger)
• SPRY domain
• B-box zinc finger
• SPRY-associated domain

KeywordsUniProt

• Cell junction
• Coiled coil
• Cytoplasm
• Metal-binding
• Nucleus
• Transferase
• Ubl conjugation pathway
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of TRIM15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TRIM8
• PXN