Seroatlas · Human Serome Atlas

ERMAP

Erythroid membrane-associated protein

Also known as: BTN5, ERMAP_HUMAN, RD, SC

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96PL5
Gene
ERMAP
Ensembl
ENSG00000164010
Chromosome
1
Canonical length
475 aa
Protein class
Blood group antigen proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Golgi apparatus,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a cell surface transmembrane protein that may act as an erythroid cell receptor, possibly as a mediator of cell adhesion. Polymorphisms in this gene are responsible for the Scianna/Radin blood group system. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

475 residues, UniProt reviewed canonical sequence.

>Q96PL5|ERMAP
     1  MEMASSAGSW LSGCLIPLVF LRLSVHVSGH AGDAGKFHVA LLGGTAELLC PLSLWPGTVP
    61  KEVRWLRSPF PQRSQAVHIF RDGKDQDEDL MPEYKGRTVL VRDAQEGSVT LQILDVRLED
   121  QGSYRCLIQV GNLSKEDTVI LQVAAPSVGS LSPSAVALAV ILPVLVLLIM VCLCLIWKQR
   181  RAKEKLLYEH VTEVDNLLSD HAKEKGKLHK AVKKLRSELK LKRAAANSGW RRARLHFVAV
   241  TLDPDTAHPK LILSEDQRCV RLGDRRQPVP DNPQRFDFVV SILGSEYFTT GCHYWEVYVG
   301  DKTKWILGVC SESVSRKGKV TASPANGHWL LRQSRGNEYE ALTSPQTSFR LKEPPRCVGI
   361  FLDYEAGVIS FYNVTNKSHI FTFTHNFSGP LRPFFEPCLH DGGKNTAPLV ICSELHKSEE
   421  SIVPRPEGKG HANGDVSLKV NSSLLPPKAP ELKDIILSLP PDLGPALQEL KAPSF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ERMAP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
29 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 29 nTPM
  • epididymis: 15 nTPM
  • liver: 12 nTPM
  • thyroid gland: 12 nTPM
  • fallopian tube: 9.5 nTPM
  • pancreas: 8.9 nTPM

Single-cell type

  • erythrocyte progenitors: 99 nCPM
  • microglia: 85 nCPM
  • late spermatids: 66 nCPM
  • epididymal principal cells: 57 nCPM
  • corticotrophs: 51 nCPM
  • adrenal cortex cells: 48 nCPM

Immune cell

  • myeloid DC: 5.1 nTPM
  • intermediate monocyte: 4.5 nTPM
  • classical monocyte: 4.3 nTPM
  • T-reg: 3.2 nTPM
  • non-classical monocyte: 3.1 nTPM
  • NK-cell: 2.2 nTPM

Brain region

  • medulla oblongata: 8.4 nTPM
  • hypothalamus: 8.3 nTPM
  • white matter: 8 nTPM
  • choroid plexus: 7.6 nTPM
  • thalamus: 7.4 nTPM
  • midbrain: 7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ERMAP.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 88 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • SCIANNA BLOOD GROUP SYSTEM, SC:-1,-2

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.17
gnomAD pLI
0
gnomAD missense Z
0.71
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ERMAP as an antibody target. Whether an autoantibody or antibody against ERMAP could matter depends on whether native ERMAP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ERMAP is annotated at the cell surface, where native ERMAP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ERMAP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ERMAP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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