Seroatlas · Human Serome Atlas

CMYA5

Cardiomyopathy-associated protein 5

Also known as: C5orf10, CMYA5_HUMAN, DKFZp451G223, SPRYD2, TRIM76

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N3K9
Gene: CMYA5
Ensembl: ENSG00000164309
Chromosome: 5
Canonical length: 4069 aa
Protein class: Predicted intracellular proteins
Subcellular location: Endoplasmic reticulum,Plasma membrane

OverviewNCBI Gene

Predicted to enable identical protein binding activity and protein phosphatase inhibitor activity. Predicted to act upstream of or within negative regulation of calcineurin-NFAT signaling cascade and regulation of skeletal muscle adaptation. Predicted to be located in several cellular components, including costamere; perinuclear region of cytoplasm; and sarcoplasmic reticulum. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

4069 residues, UniProt reviewed canonical sequence.

>Q8N3K9|CMYA5
     1  MASRDSNHAG ESFLGSDGDE EATRELETEE ESEGEEDETA AESEEEPDSR LSDQDEEGKI
    61  KQEYIISDPS FSMVTVQRED SGITWETNSS RSSTPWASEE SQTSGVCSRE GSTVNSPPGN
   121  VSFIVDEVKK VRKRTHKSKH GSPSLRRKGN RKRNSFESQD VPTNKKGSPL TSASQVLTTE
   181  KEKSYTGIYD KARKKKTTSN TPPITGAIYK EHKPLVLRPV YIGTVQYKIK MFNSVKEELI
   241  PLQFYGTLPK GYVIKEIHYR KGKDASISLE PDLDNSGSNT VSKTRKLVAQ SIEDKVKEVF
   301  PPWRGALSKG SESLTLMFSH EDQKKIYADS PLNATSALEH TVPSYSSSGR AEQGIQLRHS
   361  QSVPQQPEDE AKPHEVEPPS VTPDTPATMF LRTTKEECEL ASPGTAASEN DSSVSPSFAN
   421  EVKKEDVYSA HHSISLEAAS PGLAASTQDG LDPDQEQPDL TSIERAEPVS AKLTPTHPSV
   481  KGEKEENMLE PSISLSEPLM LEEPEKEEIE TSLPIAITPE PEDSNLVEEE IVELDYPESP
   541  LVSEKPFPPH MSPEVEHKEE ELILPLLAAS SPEHVALSEE EREEIASVST GSAFVSEYSV
   601  PQDLNHELQE QEGEPVPPSN VEAIAEHAVL SEEENEEFEA YSPAAAPTSE SSLSPSTTEK
   661  TSENQSPLFS TVTPEYMVLS GDEASESGCY TPDSTSASEY SVPSLATKES LKKTIDRKSP
   721  LILKGVSEYM IPSEEKEDTG SFTPAVAPAS EPSLSPSTTE KTSECQSPLP STATSEHVVP
   781  SEGEDLGSER FTPDSKLISK YAAPLNATQE SQKKIINEAS QFKPKGISEH TVLSVDGKEV
   841  IGPSSPDLVV ASEHSFPPHT TEMTSECQAP PLSATPSEYV VLSDEEAVEL ERYTPSSTSA
   901  SEFSVPPYAT PEAQEEEIVH RSLNLKGASS PMNLSEEDQE DIGPFSPDSA FVSEFSFPPY
   961  ATQEAEKREF ECDSPICLTS PSEHTILSDE DTEEAELFSP DSASQVSIPP FRISETEKNE
  1021  LEPDSLLTAV SASGYSCFSE ADEEDIGSTA ATPVSEQFSS SQKQKAETFP LMSPLEDLSL
  1081  PPSTDKSEKA EIKPEIPTTS TSVSEYLILA QKQKTQAYLE PESEDLIPSH LTSEVEKGER
  1141  EASSSVAAIP AALPAQSSIV KEETKPASPH SVLPDSVPAI KKEQEPTAAL TLKAADEQMA
  1201  LSKVRKEEIV PDSQEATAHV SQDQKMEPQP PNVPESEMKY SVLPDMVDEP KKGVKPKLVL
  1261  NVTSELEQRK LSKNEPEVIK PYSPLKETSL SGPEALSAVK MEMKHDSKIT TTPIVLHSAS
  1321  SGVEKQVEHG PPALAFSALS EEIKKEIEPS SSTTTASVTK LDSNLTRAVK EEIPTDSSLI
  1381  TPVDRPVLTK VGKGELGSGL PPLVTSADEH SVLAEEDKVA IKGASPIETS SKHLAWSEAE
  1441  KEIKFDSLPS VSSIAEHSVL SEVEAKEVKA GLPVIKTSSS QHSDKSEEAR VEDKQDLLFS
  1501  TVCDSERLVS SQKKSLMSTS EVLEPEHELP LSLWGEIKKK ETELPSSQNV SPASKHIIPK
  1561  GKDEETASSS PELENLASGL APTLLLLSDD KNKPAVEVSS TAQGDFPSEK QDVALAELSL
  1621  EPEKKDKPHQ PLELPNAGSE FSSDLGRQSG SIGTKQAKSP ITETEDSVLE KGPAELRSRE
  1681  GKEENRELCA SSTMPAISEL SSLLREESQN EEIKPFSPKI ISLESKEPPA SVAEGGNPEE
  1741  FQPFTFSLKG LSEEVSHPAD FKKGGNQEIG PLPPTGNLKA QVMGDILDKL SEETGHPNSS
  1801  QVLQSITEPS KIAPSDLLVE QKKTEKALHS DQTVKLPDVS TSSEDKQDLG IKQFSLMREN
  1861  LPLEQSKSFM TTKPADVKET KMEEFFISPK DENWMLGKPE NVASQHEQRI AGSVQLDSSS
  1921  SNELRPGQLK AAVSSKDHTC EVRKQVLPHS AEESHLSSQE AVSALDTSSG NTETLSSKSY
  1981  SSEEVKLAEE PKSLVLAGNV ERNIAEGKEI HSLMESESLL LEKANTELSW PSKEDSQEKI
  2041  KLPPERFFQK PVSGLSVEQV KSETISSSVK TAHFPAEGVE PALGNEKEAH RSTPPFPEEK
  2101  PLEESKMVQS KVIDDADEGK KPSPEVKIPT QRKPISSIHA REPQSPESPE VTQNPPTQPK
  2161  VAKPDLPEEK GKKGISSFKS WMSSLFFGSS TPDNKVAEQE DLETQPSPSV EKAVTVIDPE
  2221  GTIPTNFNVA EKPADHSLSE VKLKTADEPR GTLVKSGDGQ NVKEKSMILS NVEDLQQPKF
  2281  ISEVSREDYG KKEISGDSEE MNINSVVTSA DGENLEIQSY SLIGEKLVME EAKTIVPPHV
  2341  TDSKRVQKPA IAPPSKWNIS IFKEEPRSDQ KQKSLLSFDV VDKVPQQPKS ASSNFASKNI
  2401  TKESEKPESI ILPVEESKGS LIDFSEDRLK KEMQNPTSLK ISEEETKLRS VSPTEKKDNL
  2461  ENRSYTLAEK KVLAEKQNSV APLELRDSNE IGKTQITLGS RSTELKESKA DAMPQHFYQN
  2521  EDYNERPKII VGSEKEKGEE KENQVYVLSE GKKQQEHQPY SVNVAESMSR ESDISLGHSL
  2581  GETQSFSLVK ATSVTEKSEA MLAEAHPEIR EAKAVGTQPH PLEESKVLVE KTKTFLPVAL
  2641  SCRDEIENHS LSQEGNLVLE KSSRDMPDHS EEKEQFRESE LSKGGSVDIT KETVKQGFQE
  2701  KAVGTQPRPL EESKVLVEKT KTFLPVVLSC HDEIENHSLS QEGNLVLEKS SRDMPDHSEE
  2761  KEQFKESELW KGGSVDITKE SMKEGFPSKE SERTLARPFD ETKSSETPPY LLSPVKPQTL
  2821  ASGASPEINA VKKKEMPRSE LTPERHTVHT IQTSKDDTSD VPKQSVLVSK HHLEAAEDTR
  2881  VKEPLSSAKS NYAQFISNTS ASNADKMVSN KEMPKEPEDT YAKGEDFTVT SKPAGLSEDQ
  2941  KTAFSIISEG CEILNIHAPA FISSIDQEES EQMQDKLEYL EEKASFKTIP LPDDSETVAC
  3001  HKTLKSRLED EKVTPLKENK QKETHKTKEE ISTDSETDLS FIQPTIPSEE DYFEKYTLID
  3061  YNISPDPEKQ KAPQKLNVEE KLSKEVTEET ISFPVSSVES ALEHEYDLVK LDESFYGPEK
  3121  GHNILSHPET QSQNSADRNV SKDTKRDVDS KSPGMPLFEA EEGVLSRTQI FPTTIKVIDP
  3181  EFLEEPPALA FLYKDLYEEA VGEKKKEEET ASEGDSVNSE ASFPSRNSDT DDGTGIYFEK
  3241  YILKDDILHD TSLTQKDQGQ GLEEKRVGKD DSYQPIAAEG EIWGKFGTIC REKSLEEQKG
  3301  VYGEGESVDH VETVGNVAMQ KKAPITEDVR VATQKISYAV PFEDTHHVLE RADEAGSHGN
  3361  EVGNASPEVN LNVPVQVSFP EEEFASGATH VQETSLEEPK ILVPPEPSEE RLRNSPVQDE
  3421  YEFTESLHNE VVPQDILSEE LSSESTPEDV LSQGKESFEH ISENEFASEA EQSTPAEQKE
  3481  LGSERKEEDQ LSSEVVTEKA QKELKKSQID TYCYTCKCPI SATDKVFGTH KDHEVSTLDT
  3541  AISAVKVQLA EFLENLQEKS LRIEAFVSEI ESFFNTIEEN CSKNEKRLEE QNEEMMKKVL
  3601  AQYDEKAQSF EEVKKKKMEF LHEQMVHFLQ SMDTAKDTLE TIVREAEELD EAVFLTSFEE
  3661  INERLLSAME STASLEKMPA AFSLFEHYDD SSARSDQMLK QVAVPQPPRL EPQEPNSATS
  3721  TTIAVYWSMN KEDVIDSFQV YCMEEPQDDQ EVNELVEEYR LTVKESYCIF EDLEPDRCYQ
  3781  VWVMAVNFTG CSLPSERAIF RTAPSTPVIR AEDCTVCWNT ATIRWRPTTP EATETYTLEY
  3841  CRQHSPEGEG LRSFSGIKGL QLKVNLQPND NYFFYVRAIN AFGTSEQSEA ALISTRGTRF
  3901  LLLRETAHPA LHISSSGTVI SFGERRRLTE IPSVLGEELP SCGQHYWETT VTDCPAYRLG
  3961  ICSSSAVQAG ALGQGETSWY MHCSEPQRYT FFYSGIVSDV HVTERPARVG ILLDYNNQRL
  4021  IFINAESEQL LFIIRHRFNE GVHPAFALEK PGKCTLHLGI EPPDSVRHK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CMYA5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0
Highest tissue expression: 747 nTPM

Expression across tissuesHPA

Tissue

tongue: 747 nTPM
skeletal muscle: 573 nTPM
heart muscle: 146 nTPM
ovary: 10 nTPM
esophagus: 6.2 nTPM
prostate: 5.7 nTPM

Single-cell type

myonuclei: 3,869 nCPM
thymic myoid cells: 2,605 nCPM
cardiomyocytes: 1,721 nCPM
podocytes: 680 nCPM
gonadotrophs: 320 nCPM
urothelial cells: 301 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 12 nTPM
midbrain: 9.3 nTPM
cerebral cortex: 9.1 nTPM
thalamus: 8.6 nTPM
medulla oblongata: 8.2 nTPM
basal ganglia: 8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0
gnomAD missense Z: -0.06
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CMYA5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CMYA5 as an antibody target. Whether an autoantibody or antibody against CMYA5 could matter depends on whether native CMYA5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CMYA5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CMYA5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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