Seroatlas · Human Serome Atlas

SPSB2

SPRY domain-containing SOCS box protein 2

Also known as: GRCC9, SPSB2_HUMAN, SSB-2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99619
Gene: SPSB2
Ensembl: ENSG00000111671
Chromosome: 12
Canonical length: 263 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of a subfamily of proteins containing a central SPRY (repeats in splA and RyR) domain and a C-terminal suppressor of cytokine signaling (SOCS) box. This protein plays a role in cell signaling. This gene is present in a gene-rich cluster on chromosome 12p13 in the vicinity of the CD4 antigen and triosephosphate isomerase genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

263 residues, UniProt reviewed canonical sequence.

>Q99619|SPSB2
     1  MGQTALAGGS SSTPTPQALY PDLSCPEGLE ELLSAPPPDL GAQRRHGWNP KDCSENIEVK
    61  EGGLYFERRP VAQSTDGARG KRGYSRGLHA WEISWPLEQR GTHAVVGVAT ALAPLQTDHY
   121  AALLGSNSES WGWDIGRGKL YHQSKGPGAP QYPAGTQGEQ LEVPERLLVV LDMEEGTLGY
   181  AIGGTYLGPA FRGLKGRTLY PAVSAVWGQC QVRIRYLGER RAEPHSLLHL SRLCVRHNLG
   241  DTRLGQVSAL PLPPAMKRYL LYQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPSB2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

kidney: 14 nTPM
lung: 12 nTPM
thyroid gland: 12 nTPM
adrenal gland: 11 nTPM
testis: 9.7 nTPM
spleen: 9.1 nTPM

Single-cell type

epicardial cells: 109 nCPM
late primary spermatocytes: 48 nCPM
breast lactating cells: 42 nCPM
alveolar cells type 1: 37 nCPM
alveolar cells type 2: 33 nCPM
respiratory ciliated cells: 28 nCPM

Immune cell

eosinophil: 24 nTPM
plasmacytoid DC: 17 nTPM
MAIT T-cell: 14 nTPM
T-reg: 14 nTPM
naive CD4 T-cell: 14 nTPM
naive B-cell: 13 nTPM

Brain region

cerebellum: 14 nTPM
cerebral cortex: 12 nTPM
medulla oblongata: 10 nTPM
pons: 9.6 nTPM
thalamus: 9.3 nTPM
basal ganglia: 9.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0.02
gnomAD missense Z: -0.61
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ubiquitin-like ligase-substrate adaptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SPSB2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPSB2 as an antibody target. Whether an autoantibody or antibody against SPSB2 could matter depends on whether native SPSB2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPSB2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPSB2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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