Seroatlas · Human Serome Atlas

TRIM22

E3 ubiquitin-protein ligase TRIM22

Also known as: GPSTAF50, RNF94, STAF50, TRI22_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IYM9
Gene
TRIM22
Ensembl
ENSG00000132274
Chromosome
11
Canonical length
498 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear bodies,Golgi apparatus
Quaternary structure
Homotrimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein is involved in innate immunity against different DNA and RNA viruses. [provided by RefSeq, Oct 2021]

Canonical amino-acid sequenceUniProt

498 residues, UniProt reviewed canonical sequence.

>Q8IYM9|TRIM22
     1  MDFSVKVDIE KEVTCPICLE LLTEPLSLDC GHSFCQACIT AKIKESVIIS RGESSCPVCQ
    61  TRFQPGNLRP NRHLANIVER VKEVKMSPQE GQKRDVCEHH GKKLQIFCKE DGKVICWVCE
   121  LSQEHQGHQT FRINEVVKEC QEKLQVALQR LIKEDQEAEK LEDDIRQERT AWKNYIQIER
   181  QKILKGFNEM RVILDNEEQR ELQKLEEGEV NVLDNLAAAT DQLVQQRQDA STLISDLQRR
   241  LRGSSVEMLQ DVIDVMKRSE SWTLKKPKSV SKKLKSVFRV PDLSGMLQVL KELTDVQYYW
   301  VDVMLNPGSA TSNVAISVDQ RQVKTVRTCT FKNSNPCDFS AFGVFGCQYF SSGKYYWEVD
   361  VSGKIAWILG VHSKISSLNK RKSSGFAFDP SVNYSKVYSR YRPQYGYWVI GLQNTCEYNA
   421  FEDSSSSDPK VLTLFMAVPP CRIGVFLDYE AGIVSFFNVT NHGALIYKFS GCRFSRPAYP
   481  YFNPWNCLVP MTVCPPSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
111 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 111 nTPM
  • lymph node: 93 nTPM
  • tonsil: 80 nTPM
  • thymus: 76 nTPM
  • appendix: 70 nTPM
  • lung: 61 nTPM

Single-cell type

  • neutrophils: 222 nCPM
  • b-cells: 190 nCPM
  • microglia: 188 nCPM
  • kupffer cells: 158 nCPM
  • hematopoietic stem cells: 154 nCPM
  • t-cells: 123 nCPM

Immune cell

  • T-reg: 198 nTPM
  • non-classical monocyte: 184 nTPM
  • total PBMC: 180 nTPM
  • plasmacytoid DC: 170 nTPM
  • naive B-cell: 161 nTPM
  • memory B-cell: 149 nTPM

Brain region

  • white matter: 92 nTPM
  • cerebral cortex: 80 nTPM
  • choroid plexus: 79 nTPM
  • cerebellum: 69 nTPM
  • spinal cord: 67 nTPM
  • medulla oblongata: 67 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRIM22.

Disease | ImmuneIEDB

Conditions an epitope on TRIM22 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.99
gnomAD pLI
0
gnomAD missense Z
0.13
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM22 as an antibody target. Whether an autoantibody or antibody against TRIM22 could matter depends on whether native TRIM22 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM22 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM22 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRIM22. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...