Seroatlas · Human Serome Atlas

TRIM4

E3 ubiquitin-protein ligase TRIM4

Also known as: RNF87, TRIM4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9C037
Gene: TRIM4
Ensembl: ENSG00000146833
Chromosome: 7
Canonical length: 500 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol
Quaternary structure: Homotrimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternatively spliced transcript variants that encode different isoforms have been described.[provided by RefSeq, Jul 2010]

Canonical amino-acid sequenceUniProt

500 residues, UniProt reviewed canonical sequence.

>Q9C037|TRIM4
     1  MEAEDIQEEL TCPICLDYFQ DPVSIECGHN FCRGCLHRNW APGGGPFPCP ECRHPSAPAA
    61  LRPNWALARL TEKTQRRRLG PVPPGLCGRH WEPLRLFCED DQRPVCLVCR ESQEHQTHAM
   121  APIDEAFESY RTGNFDIHVD EWKRRLIRLL LYHFKQEEKL LKSQRNLVAK MKKVMHLQDV
   181  EVKNATQWKD KIKSQRMRIS TEFSKLHNFL VEEEDLFLQR LNKEEEETKK KLNENTLKLN
   241  QTIASLKKLI LEVGEKSQAP TLELLQNPKE VLTRSEIQDV NYSLEAVKVK TVCQIPLMKE
   301  MLKRFQVAVN LAEDTAHPKL VFSQEGRYVK NTASASSWPV FSSAWNYFAG WRNPQKTAFV
   361  ERFQHLPCVL GKNVFTSGKH YWEVESRDSL EVAVGVCRED VMGITDRSKM SPDVGIWAIY
   421  WSAAGYWPLI GFPGTPTQQE PALHRVGVYL DRGTGNVSFY SAVDGVHLHT FSCSSVSRLR
   481  PFFWLSPLAS LVIPPVTDRK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

ovary: 35 nTPM
breast: 25 nTPM
parathyroid gland: 24 nTPM
thyroid gland: 23 nTPM
pancreas: 23 nTPM
tonsil: 22 nTPM

Single-cell type

somatotrophs: 71 nCPM
sertoli cells: 69 nCPM
parietal cells: 62 nCPM
thyrotrophs: 58 nCPM
basal prostatic cells: 57 nCPM
b-cells: 56 nCPM

Immune cell

naive CD4 T-cell: 41 nTPM
basophil: 38 nTPM
MAIT T-cell: 33 nTPM
T-reg: 33 nTPM
memory CD8 T-cell: 33 nTPM
naive CD8 T-cell: 31 nTPM

Brain region

choroid plexus: 35 nTPM
cerebellum: 34 nTPM
white matter: 29 nTPM
midbrain: 28 nTPM
hypothalamus: 27 nTPM
medulla oblongata: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.36
gnomAD pLI: 0
gnomAD missense Z: 0.11
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM4 as an antibody target. Whether an autoantibody or antibody against TRIM4 could matter depends on whether native TRIM4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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