Seroatlas · Human Serome Atlas

TRIML2

Probable E3 ubiquitin-protein ligase TRIML2

Also known as: FLJ25801, SPRYD6, TRIMM_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N7C3
Gene
TRIML2
Ensembl
ENSG00000179046
Chromosome
4
Canonical length
437 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a member of the tri-partite motif (TRIM) family of proteins. This protein may be regulated by the tumor suppressor p53 and may regulate p53 through the enhancement of p53 SUMOylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Canonical amino-acid sequenceUniProt

437 residues, UniProt reviewed canonical sequence.

>Q8N7C3|TRIML2
     1  MSKRLSPQLQ HNITEDAYCE THLEPTRLFC DVDQITLCSK CFQSQEHKHH MVCGIQEAAE
    61  NYRKLFQEIL NTSREKLEAA KSILTDEQER MAMIQEEEQN FKKMIESEYS MRLRLLNEEC
   121  EQNLQRQQEC ISDLNLRETL LNQAIKLATE LEEMFQEMLQ RLGRVGRENM EKLKESEARA
   181  SEQVRSLLKL IVELEKKCGE GTLALLKNAK YSLERSKSLL LEHLEPAHIT DLSLCHIRGL
   241  SSMFRVLQRH LTLDPETAHP CLALSEDLRT MRLRHGQQDG AGNPERLDFS AMVLAAESFT
   301  SGRHYWEVDV EKATRWQVGI YHGSADAKGS TARASGEKVL LTGSVMGTEW TLWVFPPLKR
   361  LFLEKKLDTV GVFLDCEHGQ ISFYNVTEMS LIYNFSHCAF QGALRPVFSL CIPNGDTSPD
   421  SLTILQHGPS CDATVSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIML2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
3.8 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 3.8 nTPM
  • testis: 2.4 nTPM
  • basal ganglia: 0.4 nTPM
  • cerebral cortex: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • adipose tissue: 0 nTPM

Single-cell type

  • early spermatids: 26 nCPM
  • migrating cytotrophoblasts: 24 nCPM
  • early primary spermatocytes: 24 nCPM
  • cytotrophoblasts: 20 nCPM
  • syncytiotrophoblasts: 15 nCPM
  • ocular epithelial cells: 13 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • basal ganglia: 0.5 nTPM
  • cerebral cortex: 0.4 nTPM
  • amygdala: 0.2 nTPM
  • hippocampal formation: 0.1 nTPM
  • white matter: 0.1 nTPM
  • cerebellum: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.29
gnomAD pLI
0
gnomAD missense Z
0.12
DepMap mean gene effect
0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIML2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIML2 as an antibody target. Whether an autoantibody or antibody against TRIML2 could matter depends on whether native TRIML2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIML2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIML2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRIML2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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