SPRYD3
SPRY domain-containing protein 3
Also known as: FLJ14800, SPRY3_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8NCJ5
- Gene
- SPRYD3
- Ensembl
- ENSG00000167778
- Chromosome
- 12
- Canonical length
- 442 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Vesicles,Plasma membrane,Actin filaments,Cytosol
OverviewNCBI Gene
No narrative summary is available for SPRYD3 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
442 residues, UniProt reviewed canonical sequence.
>Q8NCJ5|SPRYD3
1 MRRTRRPRFV LMNKMDDLNL HYRFLNWRRR IREIREVRAF RYQERFKHIL VDGDTLSYHG
61 NSGEVGCYVA SRPLTKDSNY FEVSIVDSGV RGTIAVGLVP QYYSLDHQPG WLPDSVAYHA
121 DDGKLYNGRA KGRQFGSKCN SGDRIGCGIE PVSFDVQTAQ IFFTKNGKRV GSTIMPMSPD
181 GLFPAVGMHS LGEEVRLHLN AELGREDDSV MMVDSYEDEW GRLHDVRVCG TLLEYLGKGK
241 SIVDVGLAQA RHPLSTRSHY FEVEIVDPGE KCYIALGLAR KDYPKNRHPG WSRGSVAYHA
301 DDGKIFHGSG VGDPFGPRCY KGDIMGCGIM FPRDYILDSE GDSDDSCDTV ILSPTARAVR
361 NVRNVMYLHQ EGEEEEEEEE EEEDGEEIEP EHEGRKVVVF FTRNGKIIGK KDAVVPSGGF
421 FPTIGMLSCG EKVKVDLHPL SGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SPRYD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.35
- Highest tissue expression
- 134 nTPM
Expression across tissuesHPA
Tissue
- basal ganglia: 134 nTPM
- cerebral cortex: 130 nTPM
- amygdala: 82 nTPM
- hippocampal formation: 75 nTPM
- blood vessel: 74 nTPM
- hypothalamus: 72 nTPM
Single-cell type
- fallopian tube ciliated cells: 46 nCPM
- pancreatic islet cells: 41 nCPM
- epididymal principal cells: 38 nCPM
- respiratory ciliated cells: 36 nCPM
- peritubular myoid cells: 36 nCPM
- vascular smooth muscle cells: 36 nCPM
Immune cell
- eosinophil: 48 nTPM
- non-classical monocyte: 33 nTPM
- gdT-cell: 33 nTPM
- MAIT T-cell: 31 nTPM
- basophil: 30 nTPM
- intermediate monocyte: 29 nTPM
Brain region
- cerebral cortex: 167 nTPM
- basal ganglia: 155 nTPM
- white matter: 132 nTPM
- hippocampal formation: 131 nTPM
- pons: 122 nTPM
- hypothalamus: 122 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.51
- gnomAD pLI
- 0.15
- gnomAD missense Z
- 2.35
- DepMap mean gene effect
- -0.08
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- B30.2/SPRY domain
- SPRY domain
- Concanavalin A-like lectin/glucanase domain superfamily
- B30.2/SPRY domain superfamily
- Ubiquitination and Signaling Pathway Regulator
- SPRY domain
- SPRY domain-containing protein 3, SPRY domain
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SPRYD3 as an antibody target. Whether an autoantibody or antibody against SPRYD3 could matter depends on whether native SPRYD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SPRYD3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SPRYD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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