Seroatlas · Human Serome Atlas

SPRYD7

SPRY domain-containing protein 7

Also known as: C13orf1, CLLD6, SPRY7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5W111
Gene: SPRYD7
Ensembl: ENSG00000123178
Chromosome: 13
Canonical length: 196 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

No narrative summary is available for SPRYD7 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

196 residues, UniProt reviewed canonical sequence.

>Q5W111|SPRYD7
     1  MATSVLCCLR CCRDGGTGHI PLKEMPAVQL DTQHMGTDVV IVKNGRRICG TGGCLASAPL
    61  HQNKSYFEFK IQSTGIWGIG VATQKVNLNQ IPLGRDMHSL VMRNDGALYH NNEEKNRLPA
   121  NSLPQEGDVV GITYDHVELN VYLNGKNMHC PASGIRGTVY PVVYVDDSAI LDCQFSEFYH
   181  TPPPGFEKIL FEQQIF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPRYD7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 22 nTPM
cerebral cortex: 15 nTPM
hypothalamus: 15 nTPM
tongue: 14 nTPM
amygdala: 12 nTPM
hippocampal formation: 12 nTPM

Single-cell type

late primary spermatocytes: 283 nCPM
alveolar cells type 1: 178 nCPM
early spermatids: 106 nCPM
early primary spermatocytes: 105 nCPM
parietal cells: 87 nCPM
esophageal apical cells: 85 nCPM

Immune cell

NK-cell: 6.8 nTPM
memory B-cell: 5.3 nTPM
non-classical monocyte: 4.6 nTPM
naive B-cell: 4.3 nTPM
MAIT T-cell: 4.1 nTPM
T-reg: 3.1 nTPM

Brain region

cerebral cortex: 20 nTPM
hypothalamus: 20 nTPM
pons: 18 nTPM
basal ganglia: 18 nTPM
midbrain: 17 nTPM
white matter: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0
gnomAD missense Z: 1.33
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

B30.2/SPRY domain
SPRY domain
Concanavalin A-like lectin/glucanase domain superfamily
B30.2/SPRY domain superfamily
SPRY domain
SPRY domain-containing protein 7

KeywordsUniProt

Acetylation

InteractionsUniProt · HPA

Protein binding partners of SPRYD7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

VAC14

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPRYD7 as an antibody target. Whether an autoantibody or antibody against SPRYD7 could matter depends on whether native SPRYD7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPRYD7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPRYD7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...