Seroatlas · Human Serome Atlas

BTN2A3P

Putative butyrophilin subfamily 2 member A3

Also known as: BT2A3_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96KV6
Gene: BTN2A3P
Canonical length: 586 aa

OverviewNCBI Gene

No narrative summary is available for BTN2A3P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

586 residues, UniProt reviewed canonical sequence.

>Q96KV6|BTN2A3P
     1  MEPAAALHFS RPASLLLLLS LCALVSAQVT VVGPTDPILA MVGENTTLRC CLSPEENAED
    61  MEVRWFQSQF SPAVFVYKGG RERTEEQKEE YRGRTTFVSK DSRGSVALII HNVTAEDNGI
   121  YQCYFQEGRS CNEAILHLVV AGLDSEPVIE MRDHEDGGIQ LECISGGWYP KPLTVWRDPY
   181  GEVVPALKEV STPDADSLFM VTTAVIIRDK SVRNVSCSIN DTLLGQKKES VIFIPESFMP
   241  SRSPCVVILP VIMIILMIPI AICIYWINNL QKEKKDSHLM TFNLCLSLAG WRRTFLHAAN
   301  VVLDQDTGHP YLFVSEDKRS VTLDPSRESI PGNPERFDSQ LCVLGQESFA SGKHYLEVDV
   361  ENVIEWTVGI CRDNVERKWE VPLLPQNGFW TLEMHKRKYW ALTSLKWILS LEEPLCQVGI
   421  FLDYEAGDVS FYNMRDRSHI YTFPHSAFSV PVRPFFSLGS YDSQILICSA FTGASGVTVP
   481  EEGWTLHRAG THHSPQNQFP SLTAMETSPG HLSSHCTMPL VEDTPSSPLV TQENIFQLPL
   541  SHPLQTSAPV HLLIRCGFSS SFGCNYGMES RHRELVVPQL PARKKV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BTN2A3P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.4

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

signaling receptor binding

Cellular components

external side of plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BTN2A3P as an antibody target. Whether an autoantibody or antibody against BTN2A3P could matter depends on whether native BTN2A3P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BTN2A3P is annotated at the cell surface, where native BTN2A3P is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label BTN2A3P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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