Seroatlas · Human Serome Atlas

TRIM14

Tripartite motif-containing protein 14

Also known as: KIAA0129, TRI14_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14142
Gene
TRIM14
Ensembl
ENSG00000106785
Chromosome
9
Canonical length
442 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies and its function has not been determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

442 residues, UniProt reviewed canonical sequence.

>Q14142|TRIM14
     1  MAGAATGSRT PGRSELVEGC GWRCPEHGDR VAELFCRRCR RCVCALCPVL GAHRGHPVGL
    61  ALEAAVHVQK LSQECLKQLA IKKQQHIDNI TQIEDATEKL KANAESSKTW LKGKFTELRL
   121  LLDEEEALAK KFIDKNTQLT LQVYREQADS CREQLDIMND LSNRVWSISQ EPDPVQRLQA
   181  YTATEQEMQQ QMSLGELCHP VPLSFEPVKS FFKGLVEAVE STLQTPLDIR LKESINCQLS
   241  DPSSTKPGTL LKTSPSPERS LLLKYARTPT LDPDTMHARL RLSADRLTVR CGLLGSLGPV
   301  PVLRFDALWQ VLARDCFATG RHYWEVDVQE AGAGWWVGAA YASLRRRGAS AAARLGCNRQ
   361  SWCLKRYDLE YWAFHDGQRS RLRPRDDLDR LGVFLDYEAG VLAFYDVTGG MSHLHTFRAT
   421  FQEPLYPALR LWEGAISIPR LP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
31 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 31 nTPM
  • small intestine: 29 nTPM
  • duodenum: 28 nTPM
  • spleen: 25 nTPM
  • lymph node: 24 nTPM
  • liver: 22 nTPM

Single-cell type

  • kupffer cells: 294 nCPM
  • macrophages: 109 nCPM
  • monocyte progenitors: 108 nCPM
  • neutrophil progenitors: 83 nCPM
  • prostatic hillock cells: 82 nCPM
  • cone photoreceptor cells: 81 nCPM

Immune cell

  • non-classical monocyte: 59 nTPM
  • intermediate monocyte: 28 nTPM
  • T-reg: 23 nTPM
  • memory CD4 T-cell: 17 nTPM
  • total PBMC: 17 nTPM
  • MAIT T-cell: 16 nTPM

Brain region

  • medulla oblongata: 33 nTPM
  • thalamus: 24 nTPM
  • spinal cord: 23 nTPM
  • white matter: 22 nTPM
  • amygdala: 22 nTPM
  • midbrain: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.87
gnomAD pLI
0
gnomAD missense Z
0.82
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIM14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM14 as an antibody target. Whether an autoantibody or antibody against TRIM14 could matter depends on whether native TRIM14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRIM14. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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