Seroatlas · Human Serome Atlas

TRIM43

Tripartite motif-containing protein 43

Also known as: TRI43_HUMAN, TRIM43A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96BQ3
Gene: TRIM43
Ensembl: ENSG00000144015
Chromosome: 2
Canonical length: 446 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response and regulation of gene expression. Predicted to be located in centrosome. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

446 residues, UniProt reviewed canonical sequence.

>Q96BQ3|TRIM43
     1  MDSDFSHAFQ KELTCVICLN YLVDPVTICC GHSFCRPCLC LSWEEAQSPA NCPACREPSP
    61  KMDFKTNILL KNLVTIARKA SLWQFLSSEK QICGTHRQTK KMFCDMDKSL LCLLCSNSQE
   121  HGAHKHHPIE EAAEEHREKL LKQMRILWKK IQENQRNLYE EGRTAFLWRG NVVLRAQMIR
   181  NEYRKLHPVL HKEEKQHLER LNKEYQEIFQ QLQRSWVKMD QKSKHLKEMY QELMEMCHKP
   241  DVELLQDLGD IVARSESVLL HMPQPVNPEL TAGPITGLVY RLNRFRVEIS FHFEVTNHNI
   301  RLFEDVRSWM FRRGPLNSDR SDYFAAWGAR VFSFGKHYWE LDVDNSCDWA LGVCNNSWIR
   361  KNSTMVNSED IFLLLCLKVD NHFNLLTTSP VFPHYIEKPL GRVGVFLDFE SGSVSFLNVT
   421  KSSLIWSYPA GSLTFPVRPF FYTGHR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM43 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 0.4 nTPM

Expression across tissuesHPA

Tissue

testis: 0.4 nTPM
thymus: 0.3 nTPM
stomach: 0.2 nTPM
amygdala: 0.1 nTPM
cerebellum: 0.1 nTPM
parathyroid gland: 0.1 nTPM

Single-cell type

gastric chief cells: 1.1 nCPM
undifferentiated spermatogonia: 0.4 nCPM
early spermatids: 0.1 nCPM
ocular epithelial cells: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0.2 nTPM
cerebellum: 0.1 nTPM
cerebral cortex: 0.1 nTPM
basal ganglia: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.92
gnomAD pLI: 0.01
gnomAD missense Z: -0.13
DepMap mean gene effect: -0.32
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM43 as an antibody target. Whether an autoantibody or antibody against TRIM43 could matter depends on whether native TRIM43 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM43 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM43 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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