Seroatlas · Human Serome Atlas

TRIM51

Tripartite motif-containing protein 51

Also known as: SPRYD5, TRI51_HUMAN, TRIM51A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BSJ1
Gene: TRIM51
Ensembl: ENSG00000124900
Chromosome: 11
Canonical length: 452 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli,Vesicles

OverviewNCBI Gene

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

452 residues, UniProt reviewed canonical sequence.

>Q9BSJ1|TRIM51
     1  MNSGILQVFQ RALTCPICMN YFLDPVTIDC GHSFCRPCLY LNWQDTAVLA QCSECKKTTR
    61  QRNLNTDICL KNMAFIARKA SLRQFLSSEE QICGMHRETK KMFCEVDKSL LCLPCSNSQE
   121  HRNHIHCPIE WAAEERREEL LKKMQSLWEK ACENLRNLNM ETTRTRCWKD YVSLRIEAIR
   181  AEYQKMPAFL HEEEQHHLER LRKEGEDIFQ QLNESKARME HSRELLRGMY EDLKQMCHKA
   241  DVELLQAFGD ILHRYESLLL QVSEPVNPEL SAGPITGLLD SLSGFRVDFT LQPERANSHI
   301  FLCGDLRSMN VGCDPQDDPD ITGKSECFLV WGAQAFTSGK YYWEVHMGDS WNWAFGVCNN
   361  YWKEKRQNDK IDGEEGLFLL GCVKEDTHCS LFTTSPLVVQ YVPRPTSTVG LFLDCEGRTV
   421  SFVDVDQSSL IYTIPNCSFS PPLRPIFCCS HF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM51 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 0.2 nTPM

Expression across tissuesHPA

Tissue

testis: 0.2 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

undifferentiated spermatogonia: 1 nCPM
melanocytes: 0.2 nCPM
early spermatids: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM

Immune cell

basophil: 11 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.9 nTPM
basal ganglia: 0.6 nTPM
white matter: 0.5 nTPM
amygdala: 0.4 nTPM
hippocampal formation: 0.4 nTPM
hypothalamus: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.41
gnomAD pLI: 0
gnomAD missense Z: -1.14

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM51 as an antibody target. Whether an autoantibody or antibody against TRIM51 could matter depends on whether native TRIM51 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM51 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM51 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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