Seroatlas · Human Serome Atlas

TRIM75

Tripartite motif-containing protein 75

Also known as: TRI75_HUMAN, TRIM75P

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NK02
Gene: TRIM75
Ensembl: ENSG00000250374
Chromosome: 4
Canonical length: 468 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in female meiosis I; innate immune response; and regulation of gene expression. Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

468 residues, UniProt reviewed canonical sequence.

>A6NK02|TRIM75
     1  MAVAAALTGL QAEAKCSICL DYLSDPVTIE CGHNFCRSCI QQSWLDLQEL FPCPVCRHQC
    61  QEGHFRSNTQ LGRMIEIAKL LQSTKSNKRK QEETTLCEKH NQPLSVFCKE DLMVLCPLCT
   121  QPPDHQGHHV RPIEKAAIHY RKRFCSYIQP LKKQLADLQK LISTQSKKPL ELREMVENQR
   181  QELSSEFEHL NQFLDREQQA VLSRLAEEEK DNQQKLSANI TAFSNYSATL KSQLSKVVEL
   241  SELSELELLS QIKIFYESEN ESSPSIFSIH LKRDGCSFPP QYSALQRIIK KFKVEIILDP
   301  ETAHPNLIVS EDKKRVRFTK RKQKVPGFPK RFTVKPVVLG FPYFHSGRHF WEIEVGDKSE
   361  WAIGICKDSL PTKARRPSSA QQECWRIELQ DDGYHAPGAF PTPLLLEVKA RAIGIFLDYE
   421  MGEISFYNMA EKSHICTFTD TFTGPLRPYF YVGPDSQPLR ICTGTVCE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM75 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 0.1 nTPM

Expression across tissuesHPA

Tissue

placenta: 0.1 nTPM
testis: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM

Single-cell type

epicardial cells: 4.5 nCPM
thymic myoid cells: 1.4 nCPM
granulosa cells: 0.8 nCPM
late primary spermatocytes: 0.7 nCPM
extravillous trophoblasts: 0.4 nCPM
myonuclei: 0.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.4 nTPM
white matter: 0.4 nTPM
cerebellum: 0.3 nTPM
medulla oblongata: 0.3 nTPM
amygdala: 0.2 nTPM
basal ganglia: 0.2 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM75 as an antibody target. Whether an autoantibody or antibody against TRIM75 could matter depends on whether native TRIM75 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM75 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM75 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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