Seroatlas · Human Serome Atlas

RFPL4A

Ret finger protein-like 4A

Also known as: RFPL4, RFPLA_HUMAN, RNF210

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NLU0
Gene: RFPL4A
Ensembl: ENSG00000223638
Chromosome: 19
Canonical length: 287 aa
Protein class: Predicted intracellular proteins
Subcellular location: Centrosome,Cytosol

OverviewNCBI Gene

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response and regulation of gene expression. Predicted to be located in female germ cell nucleus. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

287 residues, UniProt reviewed canonical sequence.

>A6NLU0|RFPL4A
     1  MAEHFKQIIR CPVCLKDLEE AVQLKCGYAC CLQCLNSLQK EPDGEGLLCR FCSVVSQKDD
    61  IKPKYKLRAL VSIIKELEPK LKSVLTMNPR MRKFQVDMTF DVDTANNYLI ISEDLRSFRS
   121  GDLSQNRKEQ AERFDTALCV LGTPRFTSGR HYWEVDVGTS QVWDVGVCKE SVNRQGKIVL
   181  SSEHGFLTVG CREGKVFAAS TVPMTPLWVS PQLHRVGIFL DVGMRSIAFY NVSDGCHIYT
   241  FIEIPVCEPW RPFFAHKRGS QDDQSILSIC SVINPSAASA PVSSEGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RFPL4A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 4.2 nTPM

Expression across tissuesHPA

Tissue

liver: 4.2 nTPM
testis: 1.8 nTPM
epididymis: 1.5 nTPM
spleen: 0.7 nTPM
appendix: 0.5 nTPM
thymus: 0.4 nTPM

Single-cell type

early spermatids: 2.9 nCPM
undifferentiated spermatogonia: 2.4 nCPM
extravillous trophoblasts: 2.1 nCPM
late primary spermatocytes: 1.3 nCPM
cdc: 1.2 nCPM
macrophages: 1.2 nCPM

Immune cell

classical monocyte: 10 nTPM
myeloid DC: 3.2 nTPM
intermediate monocyte: 2.5 nTPM
total PBMC: 2.1 nTPM
neutrophil: 1.7 nTPM
non-classical monocyte: 0.8 nTPM

Brain region

cerebral cortex: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.74
gnomAD pLI: 0.04
gnomAD missense Z: 1.32

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RFPL4A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RFPL4A as an antibody target. Whether an autoantibody or antibody against RFPL4A could matter depends on whether native RFPL4A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RFPL4A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RFPL4A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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