Seroatlas · Human Serome Atlas

BTNL8

Butyrophilin-like protein 8

Also known as: BTN9.2, BTNL8_HUMAN, FLJ21458

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UX41
Gene: BTNL8
Ensembl: ENSG00000113303
Chromosome: 5
Canonical length: 500 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable signaling receptor binding activity. Predicted to be involved in T cell receptor signaling pathway and regulation of cytokine production. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

500 residues, UniProt reviewed canonical sequence.

>Q6UX41|BTNL8
     1  MALMLSLVLS LLKLGSGQWQ VFGPDKPVQA LVGEDAAFSC FLSPKTNAEA MEVRFFRGQF
    61  SSVVHLYRDG KDQPFMQMPQ YQGRTKLVKD SIAEGRISLR LENITVLDAG LYGCRISSQS
   121  YYQKAIWELQ VSALGSVPLI SITGYVDRDI QLLCQSSGWF PRPTAKWKGP QGQDLSTDSR
   181  TNRDMHGLFD VEISLTVQEN AGSISCSMRH AHLSREVESR VQIGDTFFEP ISWHLATKVL
   241  GILCCGLFFG IVGLKIFFSK FQWKIQAELD WRRKHGQAEL RDARKHAVEV TLDPETAHPK
   301  LCVSDLKTVT HRKAPQEVPH SEKRFTRKSV VASQSFQAGK HYWEVDGGHN KRWRVGVCRD
   361  DVDRRKEYVT LSPDHGYWVL RLNGEHLYFT LNPRFISVFP RTPPTKIGVF LDYECGTISF
   421  FNINDQSLIY TLTCRFEGLL RPYIEYPSYN EQNGTPIVIC PVTQESEKEA SWQRASAIPE
   481  TSNSESSSQA TTPFLPRGEM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BTNL8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 112 nTPM

Expression across tissuesHPA

Tissue

duodenum: 112 nTPM
small intestine: 81 nTPM
colon: 25 nTPM
rectum: 24 nTPM
bone marrow: 6.9 nTPM
stomach: 6.8 nTPM

Single-cell type

enterocytes: 415 nCPM
neutrophils: 345 nCPM
colonocytes: 177 nCPM
foveolar cells: 163 nCPM
sertoli cells: 160 nCPM
goblet cells: 150 nCPM

Immune cell

neutrophil: 234 nTPM
eosinophil: 20 nTPM
classical monocyte: 1 nTPM
non-classical monocyte: 0.5 nTPM
intermediate monocyte: 0.4 nTPM
T-reg: 0.4 nTPM

Brain region

hypothalamus: 0.7 nTPM
pons: 0.7 nTPM
medulla oblongata: 0.6 nTPM
midbrain: 0.5 nTPM
thalamus: 0.5 nTPM
white matter: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.04
gnomAD pLI: 0
gnomAD missense Z: -0.09
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

signaling receptor binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BTNL8 as an antibody target. Whether an autoantibody or antibody against BTNL8 could matter depends on whether native BTNL8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BTNL8 is annotated at the cell surface, where native BTNL8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label BTNL8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...