Seroatlas · Human Serome Atlas

FBXO45

F-box/SPRY domain-containing protein 1

Also known as: FBSP1_HUMAN, Fbx45

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0C2W1
Gene
FBXO45
Ensembl
ENSG00000174013
Chromosome
3
Canonical length
286 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles,Plasma membrane,Cytosol
Secretome location
Secreted in other tissues

OverviewNCBI Gene

Members of the F-box protein family, such as FBXO45, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (summary by Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Jan 2011]

Canonical amino-acid sequenceUniProt

286 residues, UniProt reviewed canonical sequence.

>P0C2W1|FBXO45
     1  MAAPAPGAGA ASGGAGCSGG GAGAGAGSGS GAAGAGGRLP SRVLELVFSY LELSELRSCA
    61  LVCKHWYRCL HGDENSEVWR SLCARSLAEE ALRTDILCNL PSYKAKIRAF QHAFSTNDCS
   121  RNVYIKKNGF TLHRNPIAQS TDGARTKIGF SEGRHAWEVW WEGPLGTVAV IGIATKRAPM
   181  QCQGYVALLG SDDQSWGWNL VDNNLLHNGE VNGSFPQCNN APKYQIGERI RVILDMEDKT
   241  LAFERGYEFL GVAFRGLPKV CLYPAVSAVY GNTEVTLVYL GKPLDG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FBXO45 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
13 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 13 nTPM
  • skeletal muscle: 13 nTPM
  • skin: 12 nTPM
  • cerebellum: 12 nTPM
  • cerebral cortex: 11 nTPM
  • testis: 11 nTPM

Single-cell type

  • esophageal apical cells: 40 nCPM
  • differentiating spermatogonia: 37 nCPM
  • erythrocyte progenitors: 33 nCPM
  • neutrophil progenitors: 33 nCPM
  • early primary spermatocytes: 29 nCPM
  • thymic myoid cells: 27 nCPM

Immune cell

  • T-reg: 1.6 nTPM
  • MAIT T-cell: 1.4 nTPM
  • plasmacytoid DC: 1.4 nTPM
  • basophil: 1.3 nTPM
  • myeloid DC: 1.2 nTPM
  • eosinophil: 1.1 nTPM

Brain region

  • spinal cord: 17 nTPM
  • cerebellum: 17 nTPM
  • thalamus: 17 nTPM
  • white matter: 17 nTPM
  • basal ganglia: 17 nTPM
  • cerebral cortex: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.27
gnomAD pLI
0.97
gnomAD missense Z
2.34
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FBXO45 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FBXO45 as an antibody target. Whether an autoantibody or antibody against FBXO45 could matter depends on whether native FBXO45 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FBXO45 is annotated at the cell surface, where native FBXO45 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FBXO45 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FBXO45. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...