Seroatlas · Human Serome Atlas

TRIM16

Tripartite motif-containing protein 16

Also known as: EBBP, TRI16_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95361
Gene
TRIM16
Ensembl
ENSG00000221926
Chromosome
17
Canonical length
564 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a tripartite motif (TRIM) family member that contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family. While it lacks a RING domain found in other TRIM proteins, the encoded protein can homodimerize or heterodimerize with other TRIM proteins and has E3 ubiquitin ligase activity. This gene is also a tumor suppressor and is involved in secretory autophagy. [provided by RefSeq, Jan 2017]

Canonical amino-acid sequenceUniProt

564 residues, UniProt reviewed canonical sequence.

>O95361|TRIM16
     1  MAELDLMAPG PLPRATAQPP APLSPDSGSP SPDSGSASPV EEEDVGSSEK LGRETEEQDS
    61  DSAEQGDPAG EGKEVLCDFC LDDTRRVKAV KSCLTCMVNY CEEHLQPHQV NIKLQSHLLT
   121  EPVKDHNWRY CPAHHSPLSA FCCPDQQCIC QDCCQEHSGH TIVSLDAARR DKEAELQCTQ
   181  LDLERKLKLN ENAISRLQAN QKSVLVSVSE VKAVAEMQFG ELLAAVRKAQ ANVMLFLEEK
   241  EQAALSQANG IKAHLEYRSA EMEKSKQELE RMAAISNTVQ FLEEYCKFKN TEDITFPSVY
   301  VGLKDKLSGI RKVITESTVH LIQLLENYKK KLQEFSKEEE YDIRTQVSAV VQRKYWTSKP
   361  EPSTREQFLQ YAYDITFDPD TAHKYLRLQE ENRKVTNTTP WEHPYPDLPS RFLHWRQVLS
   421  QQSLYLHRYY FEVEIFGAGT YVGLTCKGID RKGEERNSCI SGNNFSWSLQ WNGKEFTAWY
   481  SDMETPLKAG PFRRLGVYID FPGGILSFYG VEYDTMTLVH KFACKFSEPV YAAFWLSKKE
   541  NAIRIVDLGE EPEKPAPSLV GTAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
142 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 142 nTPM
  • vagina: 69 nTPM
  • cervix: 52 nTPM
  • skin: 43 nTPM
  • tonsil: 36 nTPM
  • salivary gland: 35 nTPM

Single-cell type

  • sertoli cells: 44 nCPM
  • myonuclei: 37 nCPM
  • oligodendrocytes: 34 nCPM
  • choroid plexus epithelial cells: 31 nCPM
  • ependymal cells: 31 nCPM
  • proximal tubule cells: 30 nCPM

Immune cell

  • T-reg: 45 nTPM
  • memory CD4 T-cell: 5 nTPM
  • classical monocyte: 3.9 nTPM
  • myeloid DC: 3 nTPM
  • naive CD8 T-cell: 2.7 nTPM
  • total PBMC: 2.5 nTPM

Brain region

  • white matter: 41 nTPM
  • cerebellum: 30 nTPM
  • medulla oblongata: 30 nTPM
  • pons: 29 nTPM
  • thalamus: 29 nTPM
  • midbrain: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.13
gnomAD pLI
0
gnomAD missense Z
0.34
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIM16 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM16 as an antibody target. Whether an autoantibody or antibody against TRIM16 could matter depends on whether native TRIM16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRIM16. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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