Seroatlas · Human Serome Atlas

TRIM68

E3 ubiquitin-protein ligase TRIM68

Also known as: FLJ10369, RNF137, SS-56, TRI68_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6AZZ1
Gene
TRIM68
Ensembl
ENSG00000167333
Chromosome
11
Canonical length
485 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of the tripartite motif-containing protein family, whose members are characterized by a """"""""""""""""""""""""""""""""really interesting new gene"""""""""""""""""""""""""""""""" (RING) finger domain, a zinc-binding B-box motif, and a coiled-coil region. Members of this family function as E3 ubiquitin ligases and are involved in a broad range of biological processes. This gene regulates the activation of nuclear receptors, such as androgen receptor, and has been implicated in development of prostate cancer cells, where its expression increases in response to a downregulation of microRNAs. In addition, this gene participates in viral defense regulation as a negative regulator of interferon-beta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Canonical amino-acid sequenceUniProt

485 residues, UniProt reviewed canonical sequence.

>Q6AZZ1|TRIM68
     1  MDPTALVEAI VEEVACPICM TFLREPMSID CGHSFCHSCL SGLWEIPGES QNWGYTCPLC
    61  RAPVQPRNLR PNWQLANVVE KVRLLRLHPG MGLKGDLCER HGEKLKMFCK EDVLIMCEAC
   121  SQSPEHEAHS VVPMEDVAWE YKWELHEALE HLKKEQEEAW KLEVGERKRT ATWKIQVETR
   181  KQSIVWEFEK YQRLLEKKQP PHRQLGAEVA AALASLQREA AETMQKLELN HSELIQQSQV
   241  LWRMIAELKE RSQRPVRWML QDIQEVLNRS KSWSLQQPEP ISLELKTDCR VLGLREILKT
   301  YAADVRLDPD TAYSRLIVSE DRKRVHYGDT NQKLPDNPER FYRYNIVLGS QCISSGRHYW
   361  EVEVGDRSEW GLGVCKQNVD RKEVVYLSPH YGFWVIRLRK GNEYRAGTDE YPILSLPVPP
   421  RRVGIFVDYE AHDISFYNVT DCGSHIFTFP RYPFPGRLLP YFSPCYSIGT NNTAPLAICS
   481  LDGED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM68 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
10 nTPM

Expression across tissuesHPA

Tissue

  • prostate: 10 nTPM
  • ovary: 9.5 nTPM
  • cervix: 9 nTPM
  • kidney: 9 nTPM
  • thyroid gland: 9 nTPM
  • cerebellum: 8.6 nTPM

Single-cell type

  • respiratory secretory cells: 15 nCPM
  • salivary duct cells: 13 nCPM
  • prostatic glandular cells: 11 nCPM
  • conjunctival goblet cells: 11 nCPM
  • undifferentiated spermatogonia: 9.2 nCPM
  • gonadotrophs: 9 nCPM

Immune cell

  • naive CD4 T-cell: 11 nTPM
  • naive CD8 T-cell: 9 nTPM
  • eosinophil: 8.9 nTPM
  • MAIT T-cell: 8.9 nTPM
  • memory CD8 T-cell: 8.9 nTPM
  • memory CD4 T-cell: 8.8 nTPM

Brain region

  • hypothalamus: 9 nTPM
  • cerebellum: 8.8 nTPM
  • thalamus: 8.7 nTPM
  • white matter: 8.5 nTPM
  • basal ganglia: 8.4 nTPM
  • midbrain: 8.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.45
gnomAD pLI
0
gnomAD missense Z
-0.21
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIM68 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM68 as an antibody target. Whether an autoantibody or antibody against TRIM68 could matter depends on whether native TRIM68 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM68 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM68 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRIM68. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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