Seroatlas · Human Serome Atlas

RFPL2

Ret finger protein-like 2

Also known as: RFPL2_HUMAN, RNF79

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75678
Gene: RFPL2
Ensembl: ENSG00000128253
Chromosome: 22
Canonical length: 378 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles,Plasma membrane

OverviewNCBI Gene

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

378 residues, UniProt reviewed canonical sequence.

>O75678|RFPL2
     1  MEVAELGFPE TAVSQSRICL CAVLCGHWDF ADMMVIRSLS LIRLEGVEGR DPVGGGNLTN
    61  KRPSCAPSPQ DLSAQWKQLE DRGASSRRVD MAALFQEASS CPVCSDYLEK PMSLECGCAV
   121  CLKCINSLQK EPHGEDLLCC CSSMVSRKNK IRRNRQLERL ASHIKELEPK LKKILQMNPR
   181  MRKFQVDMTL DANTANNFLL ISDDLRSVRS GRIRQNRQDL AERFDVSVCI LGSPRFTCGR
   241  HCWEVDVGTS TEWDLGVCRE SVHRKGRIQL TTELGFWTVS LRDGGRLSAT TVPLTFLFVD
   301  RKLQRVGIFL DMGMQNVSFF DAESGSHVYT FRSVSAEEPL RPFLAPSVPP NGDQGVLSIC
   361  PLMNSGTTDA PVRPGEAK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RFPL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 4.3 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 4.3 nTPM
prostate: 3.4 nTPM
basal ganglia: 2.3 nTPM
cerebellum: 2.1 nTPM
hypothalamus: 2 nTPM
hippocampal formation: 1.6 nTPM

Single-cell type

prostatic glandular cells: 27 nCPM
brain excitatory neurons: 12 nCPM
brain inhibitory neurons: 8.6 nCPM
retinal amacrine cells: 6.6 nCPM
erythrocyte progenitors: 5.5 nCPM
other brain neurons: 4.8 nCPM

Immune cell

memory CD4 T-cell: 0.2 nTPM
memory CD8 T-cell: 0.2 nTPM
classical monocyte: 0.1 nTPM
MAIT T-cell: 0.1 nTPM
basophil: 0 nTPM
eosinophil: 0 nTPM

Brain region

cerebral cortex: 22 nTPM
white matter: 11 nTPM
pons: 11 nTPM
basal ganglia: 10 nTPM
hippocampal formation: 9.8 nTPM
hypothalamus: 9.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.85
gnomAD pLI: 0
gnomAD missense Z: 0.01
DepMap mean gene effect: 0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RFPL2 as an antibody target. Whether an autoantibody or antibody against RFPL2 could matter depends on whether native RFPL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RFPL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RFPL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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