Seroatlas · Human Serome Atlas

RFPL4B

Ret finger protein-like 4B

Also known as: RFPLB_HUMAN, RNF211

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZWI9
Gene: RFPL4B
Ensembl: ENSG00000251258
Chromosome: 6
Canonical length: 263 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

263 residues, UniProt reviewed canonical sequence.

>Q6ZWI9|RFPL4B
     1  MAKRLQAELS CPVCLDFFSC SISLSCTHVF CFDCIQRYIL ENHDFRAMCP LCRDVVKVPA
    61  LEEWQVSVLT LMTKQHNSRL EQSLHVREEL RHFREDVTLD AATASSLLVF SNDLRSAQCK
   121  KIHHDLTKDP RLACVLGTPC FSSGQHYWEV EVGEVKSWSL GVCKEPADRK SNDLFPEHGF
   181  WISMKAGAIH ANTHLERIPA SPRLRRVGIF LDADLEEIQF FDVDNNVLIY THDGFFSLEL
   241  LCPFFCLELL GEGESGNVLT ICP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RFPL4B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 1.5 nTPM

Expression across tissuesHPA

Tissue

testis: 1.5 nTPM
kidney: 0.3 nTPM
placenta: 0.3 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM

Single-cell type

extravillous trophoblasts: 23 nCPM
undifferentiated spermatogonia: 4.6 nCPM
late primary spermatocytes: 3.3 nCPM
differentiating spermatogonia: 1.8 nCPM
migrating cytotrophoblasts: 1.6 nCPM
early primary spermatocytes: 1.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.26
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RFPL4B as an antibody target. Whether an autoantibody or antibody against RFPL4B could matter depends on whether native RFPL4B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RFPL4B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RFPL4B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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