Seroatlas · Human Serome Atlas

BTN2A1

Butyrophilin subfamily 2 member A1

Also known as: BT2.1, BT2A1_HUMAN, BTF1, BTN2.1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7KYR7
Gene
BTN2A1
Ensembl
ENSG00000112763
Chromosome
6
Canonical length
527 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Plasma membrane

OverviewNCBI Gene

This gene encodes a member of the immunoglobulin superfamily. The gene is located in a cluster of butyrophilin-like genes in the juxta-telomeric region of the major histocompatibility complex on chromosome 6. A pseudogene of this gene has been identified in this cluster. The encoded protein is an integral plasma membrane protein involved in lipid, fatty-acid, and sterol metabolism. Alterations in this gene may be associated with several disease states including metabolic syndrome. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

527 residues, UniProt reviewed canonical sequence.

>Q7KYR7|BTN2A1
     1  MESAAALHFS RPASLLLLLL SLCALVSAQF IVVGPTDPIL ATVGENTTLR CHLSPEKNAE
    61  DMEVRWFRSQ FSPAVFVYKG GRERTEEQME EYRGRTTFVS KDISRGSVAL VIHNITAQEN
   121  GTYRCYFQEG RSYDEAILHL VVAGLGSKPL ISMRGHEDGG IRLECISRGW YPKPLTVWRD
   181  PYGGVAPALK EVSMPDADGL FMVTTAVIIR DKSVRNMSCS INNTLLGQKK ESVIFIPESF
   241  MPSVSPCAVA LPIIVVILMI PIAVCIYWIN KLQKEKKILS GEKEFERETR EIALKELEKE
   301  RVQKEEELQV KEKLQEELRW RRTFLHAVDV VLDPDTAHPD LFLSEDRRSV RRCPFRHLGE
   361  SVPDNPERFD SQPCVLGRES FASGKHYWEV EVENVIEWTV GVCRDSVERK GEVLLIPQNG
   421  FWTLEMHKGQ YRAVSSPDRI LPLKESLCRV GVFLDYEAGD VSFYNMRDRS HIYTCPRSAF
   481  SVPVRPFFRL GCEDSPIFIC PALTGANGVT VPEEGLTLHR VGTHQSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BTN2A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 35 nTPM
  • blood vessel: 27 nTPM
  • spleen: 26 nTPM
  • fallopian tube: 18 nTPM
  • lung: 18 nTPM
  • urinary bladder: 18 nTPM

Single-cell type

  • neutrophils: 86 nCPM
  • microglia: 39 nCPM
  • nk-cells: 36 nCPM
  • vascular smooth muscle cells: 33 nCPM
  • breast lactating cells: 33 nCPM
  • b-cells: 33 nCPM

Immune cell

  • neutrophil: 52 nTPM
  • basophil: 44 nTPM
  • eosinophil: 30 nTPM
  • T-reg: 16 nTPM
  • memory CD8 T-cell: 12 nTPM
  • gdT-cell: 11 nTPM

Brain region

  • cerebellum: 33 nTPM
  • hypothalamus: 23 nTPM
  • pons: 21 nTPM
  • midbrain: 20 nTPM
  • medulla oblongata: 17 nTPM
  • white matter: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.83
gnomAD pLI
0
gnomAD missense Z
-0.44
DepMap mean gene effect
0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BTN2A1 as an antibody target. Whether an autoantibody or antibody against BTN2A1 could matter depends on whether native BTN2A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BTN2A1 is annotated at the cell surface, where native BTN2A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label BTN2A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BTN2A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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