Seroatlas · Human Serome Atlas

TRIM39

E3 ubiquitin-protein ligase TRIM39

Also known as: RNF23, TRI39_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9HCM9
Gene
TRIM39
Ensembl
ENSG00000204599
Chromosome
6
Canonical length
518 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified. This gene lies within the major histocompatibility complex class I region on chromosome 6. Alternate splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

518 residues, UniProt reviewed canonical sequence.

>Q9HCM9|TRIM39
     1  MAETSLLEAG ASAASTAAAL ENLQVEASCS VCLEYLKEPV IIECGHNFCK ACITRWWEDL
    61  ERDFPCPVCR KTSRYRSLRP NRQLGSMVEI AKQLQAVKRK IRDESLCPQH HEALSLFCYE
   121  DQEAVCLICA ISHTHRAHTV VPLDDATQEY KEKLQKCLEP LEQKLQEITR CKSSEEKKPG
   181  ELKRLVESRR QQILREFEEL HRRLDEEQQV LLSRLEEEEQ DILQRLRENA AHLGDKRRDL
   241  AHLAAEVEGK CLQSGFEMLK DVKSTLEKNI PRKFGGSLST ICPRDHKALL GLVKEINRCE
   301  KVKTMEVTSV SIELEKNFSN FPRQYFALRK ILKQLIADVT LDPETAHPNL VLSEDRKSVK
   361  FVETRLRDLP DTPRRFTFYP CVLATEGFTS GRHYWEVEVG DKTHWAVGVC RDSVSRKGEL
   421  TPLPETGYWR VRLWNGDKYA ATTTPFTPLH IKVKPKRVGI FLDYEAGTLS FYNVTDRSHI
   481  YTFTDTFTEK LWPLFYPGIR AGRKNAAPLT IRPPTDWE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM39 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
19 nTPM

Expression across tissuesHPA

Tissue

  • testis: 19 nTPM
  • blood vessel: 14 nTPM
  • pituitary gland: 14 nTPM
  • spleen: 14 nTPM
  • skeletal muscle: 13 nTPM
  • urinary bladder: 13 nTPM

Single-cell type

  • ependymal cells: 15 nCPM
  • choroid plexus epithelial cells: 12 nCPM
  • astrocytes: 6.9 nCPM
  • microglia: 6.7 nCPM
  • bergmann glia: 6.6 nCPM
  • oligodendrocytes: 6.4 nCPM

Immune cell

  • eosinophil: 11 nTPM
  • neutrophil: 7.4 nTPM
  • NK-cell: 6.2 nTPM
  • naive CD4 T-cell: 5 nTPM
  • memory CD8 T-cell: 4.1 nTPM
  • gdT-cell: 4 nTPM

Brain region

  • choroid plexus: 3.9 nTPM
  • medulla oblongata: 3.7 nTPM
  • cerebellum: 3.6 nTPM
  • cerebral cortex: 3 nTPM
  • hypothalamus: 3 nTPM
  • pons: 3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.27
gnomAD pLI
0.99
gnomAD missense Z
3.79
DepMap mean gene effect
0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIM39 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM39 as an antibody target. Whether an autoantibody or antibody against TRIM39 could matter depends on whether native TRIM39 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM39 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM39 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRIM39. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...