Seroatlas · Human Serome Atlas

TRIM62

E3 ubiquitin-protein ligase TRIM62

Also known as: DEAR1, FLJ10759, TRI62_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BVG3
Gene
TRIM62
Ensembl
ENSG00000116525
Chromosome
1
Canonical length
475 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Vesicles,Focal adhesion sites

OverviewNCBI Gene

Enables identical protein binding activity; transcription coactivator activity; and ubiquitin protein ligase activity. Involved in several processes, including negative regulation of viral transcription; positive regulation of NF-kappaB transcription factor activity; and positive regulation of antifungal innate immune response. Is active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

475 residues, UniProt reviewed canonical sequence.

>Q9BVG3|TRIM62
     1  MACSLKDELL CSICLSIYQD PVSLGCEHYF CRRCITEHWV RQEAQGARDC PECRRTFAEP
    61  ALAPSLKLAN IVERYSSFPL DAILNARRAA RPCQAHDKVK LFCLTDRALL CFFCDEPALH
   121  EQHQVTGIDD AFDELQRELK DQLQALQDSE REHTEALQLL KRQLAETKSS TKSLRTTIGE
   181  AFERLHRLLR ERQKAMLEEL EADTARTLTD IEQKVQRYSQ QLRKVQEGAQ ILQERLAETD
   241  RHTFLAGVAS LSERLKGKIH ETNLTYEDFP TSKYTGPLQY TIWKSLFQDI HPVPAALTLD
   301  PGTAHQRLIL SDDCTIVAYG NLHPQPLQDS PKRFDVEVSV LGSEAFSSGV HYWEVVVAEK
   361  TQWVIGLAHE AASRKGSIQI QPSRGFYCIV MHDGNQYSAC TEPWTRLNVR DKLDKVGVFL
   421  DYDQGLLIFY NADDMSWLYT FREKFPGKLC SYFSPGQSHA NGKNVQPLRI NTVRI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM62 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 12 nTPM
  • skin: 11 nTPM
  • spinal cord: 8.6 nTPM
  • hippocampal formation: 7.9 nTPM
  • midbrain: 6.9 nTPM
  • hypothalamus: 6.5 nTPM

Single-cell type

  • oligodendrocyte progenitor cells: 61 nCPM
  • oligodendrocytes: 44 nCPM
  • gonadotrophs: 38 nCPM
  • bergmann glia: 28 nCPM
  • retinal horizontal cells: 26 nCPM
  • salivary ionocytes: 24 nCPM

Immune cell

  • T-reg: 4.8 nTPM
  • eosinophil: 3.4 nTPM
  • MAIT T-cell: 2.3 nTPM
  • neutrophil: 2.3 nTPM
  • memory CD4 T-cell: 2 nTPM
  • intermediate monocyte: 1.8 nTPM

Brain region

  • white matter: 46 nTPM
  • cerebral cortex: 32 nTPM
  • basal ganglia: 31 nTPM
  • thalamus: 30 nTPM
  • pons: 29 nTPM
  • midbrain: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.16
gnomAD pLI
0
gnomAD missense Z
1.58
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIM62 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM62 as an antibody target. Whether an autoantibody or antibody against TRIM62 could matter depends on whether native TRIM62 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM62 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM62 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRIM62. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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