Seroatlas · Human Serome Atlas

TRIM26

Tripartite motif-containing protein 26

Also known as: RNF95, TRI26_HUMAN, ZNF173

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q12899
Gene: TRIM26
Ensembl: ENSG00000234127
Chromosome: 6
Canonical length: 539 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Although the function of the protein is unknown, the RING domain suggests that the protein may have DNA-binding activity. The gene localizes to the major histocompatibility complex (MHC) class I region on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2011]

Canonical amino-acid sequenceUniProt

539 residues, UniProt reviewed canonical sequence.

>Q12899|TRIM26
     1  MATSAPLRSL EEEVTCSICL DYLRDPVTID CGHVFCRSCT TDVRPISGSR PVCPLCKKPF
    61  KKENIRPVWQ LASLVENIER LKVDKGRQPG EVTREQQDAK LCERHREKLH YYCEDDGKLL
   121  CVMCRESREH RPHTAVLMEK AAQPHREKIL NHLSTLRRDR DKIQGFQAKG EADILAALKK
   181  LQDQRQYIVA EFEQGHQFLR EREEHLLEQL AKLEQELTEG REKFKSRGVG ELARLALVIS
   241  ELEGKAQQPA AELMQDTRDF LNRYPRKKFW VGKPIARVVK KKTGEFSDKL LSLQRGLREF
   301  QGKLLRDLEY KTVSVTLDPQ SASGYLQLSE DWKCVTYTSL YKSAYLHPQQ FDCEPGVLGS
   361  KGFTWGKVYW EVEVEREGWS EDEEEGDEEE EGEEEEEEEE AGYGDGYDDW ETDEDEESLG
   421  DEEEEEEEEE EEVLESCMVG VARDSVKRKG DLSLRPEDGV WALRLSSSGI WANTSPEAEL
   481  FPALRPRRVG IALDYEGGTV TFTNAESQEL IYTFTATFTR RLVPFLWLKW PGTRLLLRP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM26 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

esophagus: 27 nTPM
liver: 24 nTPM
cerebellum: 21 nTPM
skin: 20 nTPM
salivary gland: 20 nTPM
blood vessel: 20 nTPM

Single-cell type

distal convoluted tubule cells: 67 nCPM
proximal tubule cells: 62 nCPM
renal connecting tubule cells: 54 nCPM
renal collecting duct intercalated cells: 54 nCPM
loop of henle epithelial cells: 52 nCPM
papillary tip epithelial cells: 50 nCPM

Immune cell

gdT-cell: 1.9 nTPM
intermediate monocyte: 1.9 nTPM
non-classical monocyte: 1.6 nTPM
T-reg: 1.6 nTPM
classical monocyte: 1.5 nTPM
memory CD8 T-cell: 1.5 nTPM

Brain region

hypothalamus: 9.9 nTPM
white matter: 9.9 nTPM
medulla oblongata: 9.8 nTPM
thalamus: 9.7 nTPM
cerebellum: 9.6 nTPM
pons: 9.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.46
gnomAD pLI: 0.18
gnomAD missense Z: 3.09
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TRIM26 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM26 as an antibody target. Whether an autoantibody or antibody against TRIM26 could matter depends on whether native TRIM26 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM26 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM26 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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