Seroatlas · Human Serome Atlas

TRIM64C

Tripartite motif-containing protein 64C

Also known as: TR64C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NLI5
Gene: TRIM64C
Ensembl: ENSG00000214891
Chromosome: 11
Canonical length: 450 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

450 residues, UniProt reviewed canonical sequence.

>A6NLI5|TRIM64C
     1  MDSDTLRVFQ NELICCICVN YFIDPVTTDC VHSFCRPCLC LCSEEGRAPM RCPLCRKISE
    61  KPNFNTNVAL KKLASLARQT RPQNINSSDN ICVLHEETKE LFCEADKRLL CGPCSESPEH
   121  MAHSHSPIGW AAEECRVQKL IKEMDYLWKI NQETQNNLNQ ETSKFCSLVD YVSLRKVIIT
   181  IQYQKMHIFL DEEEQRHLQA LEREAKELFQ QLQDSQVRMT QHLEGMKDMY RELWETYHMP
   241  DVELLQDVGN ISARTDLAQM PKPQPVNPEL TSWCITGVLD MLNNFRVDNA LSTEMTPCYI
   301  SLSEDVRRVI FGDDHRSAPM DPQGVESFAV WCAQAFTSGK HYWEVDVTHS SNWILGVCRD
   361  SRTADTNIVI DSDKTFFSIS SKTSNHYSLS TNSPPLIQYV QRPLGWVGVF LDYDNGSVSF
   421  FDVSKGSLIY GFPPSSFSSP LRPFFCFGCT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM64C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 0 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM
blood vessel: 0 nTPM

Single-cell type

epicardial cells: 2.3 nCPM
colonocytes: 0.1 nCPM
undifferentiated spermatogonia: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM

Immune cell

basophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.51
gnomAD pLI: 0
gnomAD missense Z: 0.76

OntologyGO

Biological processes

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM64C as an antibody target. Whether an autoantibody or antibody against TRIM64C could matter depends on whether native TRIM64C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM64C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM64C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...