Seroatlas · Human Serome Atlas

SPSB1

SPRY domain-containing SOCS box protein 1

Also known as: SPSB1_HUMAN, SSB-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96BD6
Gene: SPSB1
Ensembl: ENSG00000171621
Chromosome: 1
Canonical length: 273 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables ubiquitin-like ligase-substrate adaptor activity. Involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

273 residues, UniProt reviewed canonical sequence.

>Q96BD6|SPSB1
     1  MGQKVTGGIK TVDMRDPTYR PLKQELQGLD YCKPTRLDLL LDMPPVSYDV QLLHSWNNND
    61  RSLNVFVKED DKLIFHRHPV AQSTDAIRGK VGYTRGLHVW QITWAMRQRG THAVVGVATA
   121  DAPLHSVGYT TLVGNNHESW GWDLGRNRLY HDGKNQPSKT YPAFLEPDET FIVPDSFLVA
   181  LDMDDGTLSF IVDGQYMGVA FRGLKGKKLY PVVSAVWGHC EIRMRYLNGL DPEPLPLMDL
   241  CRRSVRLALG RERLGEIHTL PLPASLKAYL LYQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPSB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 53 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 53 nTPM
adipose tissue: 50 nTPM
liver: 44 nTPM
skeletal muscle: 41 nTPM
endometrium: 37 nTPM
ovary: 32 nTPM

Single-cell type

epididymal basal cells: 427 nCPM
endometrial glandular cells: 423 nCPM
salivary myoepithelial cells: 252 nCPM
endometrial luminal cells: 234 nCPM
podocytes: 220 nCPM
endometrial secretory cells: 219 nCPM

Immune cell

basophil: 1.2 nTPM
T-reg: 0.8 nTPM
memory B-cell: 0.4 nTPM
memory CD4 T-cell: 0.3 nTPM
NK-cell: 0.3 nTPM
naive CD8 T-cell: 0.2 nTPM

Brain region

medulla oblongata: 45 nTPM
white matter: 36 nTPM
thalamus: 30 nTPM
midbrain: 27 nTPM
basal ganglia: 26 nTPM
pons: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.59
gnomAD pLI: 0.52
gnomAD missense Z: 2.21
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ubiquitin-like ligase-substrate adaptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SPSB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPSB1 as an antibody target. Whether an autoantibody or antibody against SPSB1 could matter depends on whether native SPSB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPSB1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPSB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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