Seroatlas · Human Serome Atlas

TRIM49D1

Tripartite motif-containing protein 49D

Also known as: TR49D_HUMAN, TRIM49D, TRIM49D1P, TRIM49D2, TRIM49D2P, TRIM49DP, TRIM49L, TRIM49L1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: C9J1S8
Gene: TRIM49D1
Ensembl: ENSG00000223417
Chromosome: 11
Canonical length: 452 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response and regulation of gene expression. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

452 residues, UniProt reviewed canonical sequence.

>C9J1S8|TRIM49D1
     1  MNSGISQVFQ RELTCPICLN YFIDPVTIDC GHSFCRPCFY LNWQDIPILT QCFECLKTTQ
    61  QRNLKTNIRL KKMASRARKA SLWLFLSSEE QMCGTHRETK KIFCEVDRSL LCLLCSSSLE
   121  HRYHRHCPAE WAAEEHREKL LKKMQSLWEK VCENQRNLNV ETTRISHWKD YVNVRLEAIR
   181  AEYQKMPAFH HEEEKHNLEM LKKKGKDIFH RLHLSKAKMA HRREILRGTY AELMKMCHKP
   241  DVELLQAFGD ILHRSESVLL HMPQPLNLEL RAGPITGLRD RLNQFRVDIT LPHNEANSHI
   301  FRRGDLRSIC IGCDRQNAPH ITATPTSFLA WGAQTFTSGK YYWEVHVGDS WNWAFGVCNK
   361  YWKGTNQNGN IHGEEGLFSL GCVKNDIQCS LFTTSPLTLQ YVPRPTNHVG LFLDCEARTV
   421  SFVDVNQSSP IHTIPNCSFS PPLRPIFCCV HL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRIM49D1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 3.8 nTPM

Expression across tissuesHPA

Tissue

liver: 3.8 nTPM
retina: 1.8 nTPM
bone marrow: 1.7 nTPM
kidney: 1.7 nTPM
testis: 1.5 nTPM
epididymis: 1.4 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

basophil: 15 nTPM
naive B-cell: 0.4 nTPM
naive CD4 T-cell: 0.2 nTPM
naive CD8 T-cell: 0.2 nTPM
neutrophil: 0.2 nTPM
plasmacytoid DC: 0.2 nTPM

Brain region

cerebellum: 29 nTPM
white matter: 28 nTPM
cerebral cortex: 25 nTPM
hypothalamus: 23 nTPM
basal ganglia: 23 nTPM
medulla oblongata: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.89
gnomAD pLI: 0.29
gnomAD missense Z: 0.95
DepMap mean gene effect: -0.17
DepMap dependency class: selective

OntologyGO

Biological processes

Molecular functions

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRIM49D1 as an antibody target. Whether an autoantibody or antibody against TRIM49D1 could matter depends on whether native TRIM49D1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRIM49D1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TRIM49D1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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