Seroatlas · Human Serome Atlas

RNF135

E3 ubiquitin-protein ligase RNF135

Also known as: MGC13061, RN135_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IUD6
Gene
RNF135
Ensembl
ENSG00000181481
Chromosome
17
Canonical length
432 aa
Protein class
Enzymes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Vesicles
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

432 residues, UniProt reviewed canonical sequence.

>Q8IUD6|RNF135
     1  MAGLGLGSAV PVWLAEDDLG CIICQGLLDW PATLPCGHSF CRHCLEALWG ARDARRWACP
    61  TCRQGAAQQP HLRKNTLLQD LADKYRRAAR EIQAGSDPAH CPCPGSSSLS SAAARPRRRP
   121  ELQRVAVEKS ITEVAQELTE LVEHLVDIVR SLQNQRPLSE SGPDNELSIL GKAFSSGVDL
   181  SMASPKLVTS DTAAGKIRDI LHDLEEIQEK LQESVTWKEA PEAQMQGELL EAPSSSSCPL
   241  PDQSHPALRR ASRFAQWAIH PTFNLKSLSC SLEVSKDSRT VTVSHRPQPY RWSCERFSTS
   301  QVLCSQALSS GKHYWEVDTR NCSHWAVGVA SWEMSRDQVL GRTMDSCCVE WKGTSQLSAW
   361  HMVKETVLGS DRPGVVGIWL NLEEGKLAFY SVDNQEKLLY ECTISASSPL YPAFWLYGLH
   421  PGNYLIIKQV KV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF135 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • skin: 26 nTPM
  • spleen: 26 nTPM
  • esophagus: 22 nTPM
  • adipose tissue: 21 nTPM
  • kidney: 20 nTPM
  • breast: 19 nTPM

Single-cell type

  • kupffer cells: 151 nCPM
  • hofbauer cells: 84 nCPM
  • neutrophils: 77 nCPM
  • esophageal apical cells: 69 nCPM
  • macrophages: 64 nCPM
  • cytotrophoblasts: 63 nCPM

Immune cell

  • non-classical monocyte: 71 nTPM
  • classical monocyte: 62 nTPM
  • intermediate monocyte: 57 nTPM
  • neutrophil: 54 nTPM
  • myeloid DC: 47 nTPM
  • eosinophil: 31 nTPM

Brain region

  • thalamus: 28 nTPM
  • choroid plexus: 26 nTPM
  • medulla oblongata: 23 nTPM
  • white matter: 22 nTPM
  • midbrain: 22 nTPM
  • spinal cord: 20 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RNF135.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 137 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.44
gnomAD pLI
0
gnomAD missense Z
0.09
DepMap mean gene effect
-0.1
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RNF135 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF135 as an antibody target. Whether an autoantibody or antibody against RNF135 could matter depends on whether native RNF135 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF135 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF135 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RNF135. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...