SPRY domain
IPR003877
Definition
The SPRY domain is a ~140-amino-acid protein interaction module involved in many important signalling pathways like RNA processing, regulation of histone H3 methylation, innate immunity, or embryonic development [[cite:PMID:17189197], [cite:PMID:23139046], [cite:PMID:27812363]]. It can be divided into 11 subfamilies based on amino acid sequence similarity or the presence of additional protein domains. Functionally, SPRY domains mediate critical interactions in diverse pathways: SSB-2 binds Par-4 to regulate apoptosis, RanBPM/SSB-1 interact with c-Met for signalling modulation, and SPSB proteins target iNOS for ubiquitination in immune regulation [[cite:PMID:16369487], [cite:PMID:15713673], [cite:PMID:21199876]]. The B30.2 domain was first identified as a protein domain encoded by an exon (named B30-2) in the Homo sapiens class I major histocompatibility complex region PMID:8114113, whereas the SPRY domain was first identified in a Dictyostelium discoideum kinase splA and mammalian calcium-release channels ryanodine receptors PMID:9204703. B30.2 domain consists of PRY and SPRY subdomains. The SPRY domains (after SPla and the RYanodine Receptor) are shorter at the N terminus than the B30.2 domains. The ~200-residue B30.2/SPRY (for B30.2 and/or SPRY) domain is present in a large number of proteins with diverse individual functions in different biological processes. The B30.2/SPRY domain in these proteins is likely to function through protein-protein interaction PMID:16498413. The N-terminal ~60 residues of B30.2/SPRY domains are poorly conserved and, as a consequence, a new domain name PRY was coined for a group of similar sequence segments N-terminal to the SPRY domains PMID:16498413. The B30.2/SPRY domain contains three highly conserved motifs (LDP, WEVE and LDYE) PMID:9196055. The B30.2/SPRY domain adopts a highly distorted, compact β-sandwich fold with two additional short β-helices at the N terminus. The β-sandwich of the B30.2/SPRY domain consists of two layers of β-sheets: sheet A composed of eight strands and sheet B composed of seven strands. All the β-strands are in antiparallel arrangement PMID:16498413. The 5th β-strand corresponding to WEVE motif PMID:10223295. Both the N- and C-terminal ends of the B30.2/SPRY domains in general are close to each other PMID:16498413.
93 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Download CSV (93 proteins: gene, accession, name)
- ASH2L
- BSPRY
- BTN1A1
- BTN2A1
- BTN2A2
- BTN2A3P
- BTN3A1
- BTN3A3
- BTNL3
- BTNL8
- BTNL9
- CMYA5
- DDX1
- ERMAP
- FBXO45
- FSD1
- FSD1L
- FSD2
- HERC1
- HNRNPU
- HNRNPUL1
- HNRNPUL2
- MEFV
- MID1
- MID2
- RANBP10
- RANBP9
- RFPL1
- RFPL2
- RFPL3
- RFPL4A
- RFPL4AL1
- RFPL4B
- RNF123
- RNF135
- RNF39
- RSPRY1
- RYR1
- RYR2
- RYR3
- SPRYD3
- SPRYD4
- SPRYD7
- SPSB1
- SPSB2
- SPSB3
- SPSB4
- TRIM10
- TRIM11
- TRIM14
- TRIM15
- TRIM16
- TRIM16L
- TRIM17
- TRIM21
- TRIM22
- TRIM25
- TRIM26
- TRIM27
- TRIM34
- TRIM35
- TRIM38
- TRIM39
- TRIM4
- TRIM41
- TRIM43
- TRIM43B
- TRIM49
- TRIM49B
- TRIM49C
- TRIM49D1
- TRIM5
- TRIM50
- TRIM51
- TRIM51G
- TRIM58
- TRIM6
- TRIM60
- TRIM62
- TRIM64
- TRIM64B
- TRIM64C
- TRIM65
- TRIM67
- TRIM68
- TRIM69
- TRIM7
- TRIM72
- TRIM75
- TRIM77
- TRIM9
- TRIML1
- TRIML2
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