AH/BAR domain superfamily
IPR027267
Definition
This superfamily represents a structural domain which consists of three α-helices, including the arfaptin homology (AH) domain and the BAR (Bin-Amphiphysin-Rvs) domain. The arfaptin homology (AH) domain is a protein domain found in a range of proteins, including arfaptins, protein kinase C-binding protein PICK1 PMID:10623590 and mammalian 69kDa islet cell autoantigen (ICA69) PMID:12682071. The AH domain of arfaptin has been shown to dimerise and to bind Arf and Rho family GTPases [[cite:PMID:11346801], [cite:PMID:11696355]], including ARF1, a small GTPase involved in vesicle budding at the Golgi complex and immature secretory granules. The AH domain consists of three α-helices arranged as an extended antiparallel α-helical bundle. Two arfaptin AH domains associate to form a highly elongated, crescent-shaped dimer [[cite:PMID:11346801], [cite:PMID:11696355]]. Members of the Amphiphysin protein family are key regulators in the early steps of endocytosis, involved in the formation of clathrin-coated vesicles by promoting the assembly of a protein complex at the plasma membrane and directly assist in the induction of the high curvature of the membrane at the neck of the vesicle. Amphiphysins contain a characteristic domain, known as the BAR (Bin-Amphiphysin-Rvs) domain, which is required for theirin vivofunction and their ability to tubulate membranes PMID:14993925. The crystal structure of these proteins suggest the domain forms a crescent-shaped dimer of a three-helix coiled coil with a characteristic set of conserved hydrophobic, aromatic and hydrophilic amino acids. Proteins containing this domain have been shown to homodimerise, heterodimerise or, in a few cases, interact with small GTPases.
77 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Download CSV (77 proteins: gene, accession, name)
- ACAP1
- ACAP2
- ACAP3
- AMPH
- APPL1
- APPL2
- ARFIP1
- ARFIP2
- ARHGAP10
- ARHGAP17
- ARHGAP26
- ARHGAP29
- ARHGAP4
- ARHGAP42
- ARHGAP44
- ARHGAP45
- ARHGEF37
- ARHGEF38
- ASAP1
- ASAP2
- ASAP3
- BAIAP2
- BAIAP2L1
- BAIAP2L2
- BARGIN
- BIN1
- BIN2
- BIN3
- CIBAR1
- CIBAR2
- DNMBP
- FCHO1
- FCHO2
- FCHSD1
- FCHSD2
- FER
- FES
- FNBP1
- FNBP1L
- GAS7
- GMIP
- ICA1
- ICA1L
- MTSS1
- MTSS2
- NOSTRIN
- OPHN1
- PACSIN1
- PACSIN2
- PACSIN3
- PICK1
- PSTPIP1
- PSTPIP2
- SH3BP1
- SH3GL1
- SH3GL2
- SH3GL3
- SH3GLB1
- SH3GLB2
- SNX1
- SNX18
- SNX2
- SNX30
- SNX32
- SNX33
- SNX4
- SNX5
- SNX6
- SNX7
- SNX8
- SNX9
- SRGAP1
- SRGAP2
- SRGAP2B
- SRGAP2C
- SRGAP3
- TRIP10
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