Seroatlas · Human Serome Atlas

ARFIP2

Arfaptin-2

Also known as: ARFP2_HUMAN, POR1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P53365
Gene
ARFIP2
Ensembl
ENSG00000132254
Chromosome
11
Canonical length
341 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli,Golgi apparatus
Quaternary structure
Homodimer

OverviewNCBI Gene

Enables several functions, including GTP-dependent protein binding activity; membrane curvature sensor activity; and phosphatidylinositol-4-phosphate binding activity. Involved in actin cytoskeleton organization; mitophagy; and protein localization to phagophore assembly site. Located in several cellular components, including nucleolus; ruffle; and trans-Golgi network membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

341 residues, UniProt reviewed canonical sequence.

>P53365|ARFIP2
     1  MTDGILGKAA TMEIPIHGNG EARQLPEDDG LEQDLQQVMV SGPNLNETSI VSGGYGGSGD
    61  GLIPTGSGRH PSHSTTPSGP GDEVARGIAG EKFDIVKKWG INTYKCTKQL LSERFGRGSR
   121  TVDLELELQI ELLRETKRKY ESVLQLGRAL TAHLYSLLQT QHALGDAFAD LSQKSPELQE
   181  EFGYNAETQK LLCKNGETLL GAVNFFVSSI NTLVTKTMED TLMTVKQYEA ARLEYDAYRT
   241  DLEELSLGPR DAGTRGRLES AQATFQAHRD KYEKLRGDVA IKLKFLEENK IKVMHKQLLL
   301  FHNAVSAYFA GNQKQLEQTL QQFNIKLRPP GAEKPSWLEE Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARFIP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
54 nTPM

Expression across tissuesHPA

Tissue

  • salivary gland: 54 nTPM
  • choroid plexus: 54 nTPM
  • pancreas: 54 nTPM
  • prostate: 49 nTPM
  • breast: 48 nTPM
  • stomach: 48 nTPM

Single-cell type

  • syncytiotrophoblasts: 138 nCPM
  • goblet cells: 124 nCPM
  • esophageal apical cells: 114 nCPM
  • cytotrophoblasts: 92 nCPM
  • esophageal suprabasal cells: 86 nCPM
  • extravillous trophoblasts: 83 nCPM

Immune cell

  • myeloid DC: 21 nTPM
  • NK-cell: 21 nTPM
  • T-reg: 19 nTPM
  • gdT-cell: 18 nTPM
  • MAIT T-cell: 18 nTPM
  • naive CD8 T-cell: 17 nTPM

Brain region

  • choroid plexus: 37 nTPM
  • cerebral cortex: 31 nTPM
  • white matter: 29 nTPM
  • cerebellum: 29 nTPM
  • thalamus: 28 nTPM
  • pons: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.43
gnomAD pLI
0.77
gnomAD missense Z
1.69
DepMap mean gene effect
0.17
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARFIP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARFIP2 as an antibody target. Whether an autoantibody or antibody against ARFIP2 could matter depends on whether native ARFIP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARFIP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARFIP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARFIP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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