Seroatlas · Human Serome Atlas

ICA1L

Islet cell autoantigen 1-like protein

Also known as: ALS2CR14, ALS2CR15, ICA1L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NDH6
Gene: ICA1L
Ensembl: ENSG00000163596
Chromosome: 2
Canonical length: 482 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to enable protein domain specific binding activity. Predicted to be involved in regulation of transport. Predicted to act upstream of or within spermatid development. Predicted to be located in acrosomal vesicle. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

482 residues, UniProt reviewed canonical sequence.

>Q8NDH6|ICA1L
     1  MDSFGQPRPE DNQSVVRRMQ KKYWKTKQVF IKATGKKEDE HLVASDAELD AKLEVFHSVQ
    61  ETCTELLKII EKYQLRLNVI SEEENELGLF LKFQAERDAT QAGKMMDATG KALCSSAKQR
   121  LALCTPLSRL KQEVATFSQR AVSDTLMTIN RMEQARTEYR GALLWMKDVS QELDPDTLKQ
   181  MEKFRKVQMQ VRNSKASFDK LKMDVCQKVD LLGASRCNML SHSLTTYQRT LLGFWKKTAR
   241  MMSQIHEACI GFHPYDFVAL KQLQDTPSKI SEDNKDEQIG GFLTEQLNKL VLSDEEASFE
   301  SEQANKDHNE KHSQMREFGA PQFSNSENVA KDLPVDSLEG EDFEKEFSFL NNLLSSGSSS
   361  TSEFTQECQT AFGSPSASLT SQEPSMGSEP LAHSSRFLPS QLFDLGFHVA GAFNNWVSQE
   421  ESELCLSHTD NQPVPSQSPK KLTRSPNNGN QDMSAWFNLF ADLDPLSNPD AIGHSDDELL
   481  NA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ICA1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 24 nTPM
retina: 16 nTPM
pituitary gland: 15 nTPM
cerebral cortex: 13 nTPM
hypothalamus: 12 nTPM
basal ganglia: 11 nTPM

Single-cell type

somatotrophs: 311 nCPM
brain excitatory neurons: 269 nCPM
ependymal cells: 256 nCPM
lactotrophs: 242 nCPM
thyrotrophs: 232 nCPM
other brain neurons: 206 nCPM

Immune cell

naive B-cell: 2.2 nTPM
NK-cell: 2.2 nTPM
non-classical monocyte: 2 nTPM
myeloid DC: 1.6 nTPM
naive CD8 T-cell: 1.6 nTPM
neutrophil: 1.5 nTPM

Brain region

cerebellum: 88 nTPM
cerebral cortex: 82 nTPM
hypothalamus: 70 nTPM
hippocampal formation: 69 nTPM
basal ganglia: 63 nTPM
white matter: 57 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.64
gnomAD pLI: 0
gnomAD missense Z: 0.92
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ICA1L as an antibody target. Whether an autoantibody or antibody against ICA1L could matter depends on whether native ICA1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ICA1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ICA1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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