ARHGAP26

Protein identityUniProt · HPA

UniProt accession

Q9UNA1

Gene

ARHGAP26

Ensembl

ENSG00000145819

Chromosome

5

Canonical length

814 aa

Protein class

Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Cytosol

OverviewNCBI Gene

Interaction of a cell with the extracellular matrix triggers integrin cell surface receptors to begin signaling cascades that regulate the organization of the actin-cytoskeleton. One of the proteins involved in these cascades is focal adhesion kinase. The protein encoded by this gene is a GTPase activating protein that binds to focal adhesion kinase and mediates the activity of the GTP binding proteins RhoA and Cdc42. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2017]

Canonical amino-acid sequenceUniProt

814 residues, UniProt reviewed canonical sequence.

>Q9UNA1|ARHGAP26
     1  MGLPALEFSD CCLDSPHFRE TLKSHEAELD KTNKFIKELI KDGKSLISAL KNLSSAKRKF
    61  ADSLNEFKFQ CIGDAETDDE MCIARSLQEF ATVLRNLEDE RIRMIENASE VLITPLEKFR
   121  KEQIGAAKEA KKKYDKETEK YCGILEKHLN LSSKKKESQL QEADSQVDLV RQHFYEVSLE
   181  YVFKVQEVQE RKMFEFVEPL LAFLQGLFTF YHHGYELAKD FGDFKTQLTI SIQNTRNRFE
   241  GTRSEVESLM KKMKENPLEH KTISPYTMEG YLYVQEKRHF GTSWVKHYCT YQRDSKQITM
   301  VPFDQKSGGK GGEDESVILK SCTRRKTDSI EKRFCFDVEA VDRPGVITMQ ALSEEDRRLW
   361  MEAMDGREPV YNSNKDSQSE GTAQLDSIGF SIIRKCIHAV ETRGINEQGL YRIVGVNSRV
   421  QKLLSVLMDP KTASETETDI CAEWEIKTIT SALKTYLRML PGPLMMYQFQ RSFIKAAKLE
   481  NQESRVSEIH SLVHRLPEKN RQMLQLLMNH LANVANNHKQ NLMTVANLGV VFGPTLLRPQ
   541  EETVAAIMDI KFQNIVIEIL IENHEKIFNT VPDMPLTNAQ LHLSRKKSSD SKPPSCSERP
   601  LTLFHTVQST EKQEQRNSII NSSLESVSSN PNSILNSSSS LQPNMNSSDP DLAVVKPTRP
   661  NSLPPNPSPT SPLSPSWPMF SAPSSPMPTS STSSDSSPVR SVAGFVWFSV AAVVLSLARS
   721  SLHAVFSLLV NFVPCHPNLH LLFDRPEEAV HEDSSTPFRK AKALYACKAE HDSELSFTAG
   781  TVFDNVHPSQ EPGWLEGTLN GKTGLIPENY VEFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARHGAP26 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.39

Highest tissue expression

34 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ARHGAP26.

Disease | AllUniProt

Conditions ARHGAP26 is implicated in, by any mechanism.

• Leukemia, juvenile myelomonocytic (JMML) MIM:607785

Disease | AutoantibodyPubMed

Conditions in which antibodies against ARHGAP26 are reported. Each links to that disease's full target list.

• Cerebellar Ataxia 3

ReferencesPubMed · IEDB

Publications for ARHGAP26 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.28

gnomAD pLI

1

gnomAD missense Z

2.11

DepMap mean gene effect

0.03

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• actin cytoskeleton organization
• mitophagy
• regulation of small GTPase mediated signal transduction
• signal transduction

Molecular functions

• GTPase activator activity
• phospholipid binding
• protein-macromolecule adaptor activity

Cellular components

• cytoskeleton
• cytosol
• endosome membrane
• focal adhesion
• mitochondrion

Protein domainsUniProt · Pfam · InterPro

• Rho GTPase-activating protein domain
• SH3 domain
• Pleckstrin homology domain
• BAR domain
• Rho GTPase activation protein
• PH-like domain superfamily
• AH/BAR domain superfamily
• SH3-like domain superfamily
• GRAF, PH domain
• GRAF family
• PH domain
• RhoGAP domain
• Variant SH3 domain
• BAR domain of APPL family
• GRAF, SH3 domain
• GRAF, BAR domain

KeywordsUniProt

• Cell junction
• Chromosomal rearrangement
• Cytoplasm
• Cytoskeleton
• Endosome
• GTPase activation
• Membrane
• Phosphoprotein
• Proto-oncogene
• SH3 domain

InteractionsUniProt · HPA

Protein binding partners of ARHGAP26 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MICAL1
• MYO16
• NYAP1
• NYAP2
• WDR44
• PTK2B
• PTK2
• ARHGAP10
• PKN3