SNX18

Protein identityUniProt · HPA

UniProt accession

Q96RF0

Gene

SNX18

Ensembl

ENSG00000178996

Chromosome

5

Canonical length

628 aa

Protein class

Plasma proteins, Predicted intracellular proteins

Subcellular location

Cytosol

OverviewNCBI Gene

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a SH3 domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

628 residues, UniProt reviewed canonical sequence.

>Q96RF0|SNX18
     1  MALRARALYD FRSENPGEIS LREHEVLSLC SEQDIEGWLE GVNSRGDRGL FPASYVQVIR
    61  APEPGPAGDG GPGAPARYAN VPPGGFEPLP VAPPASFKPP PDAFQALLQP QQAPPPSTFQ
   121  PPGAGFPYGG GALQPSPQQL YGGYQASQGS DDDWDDEWDD SSTVADEPGA LGSGAYPDLD
   181  GSSSAGVGAA GRYRLSTRSD LSLGSRGGSV PPQHHPSGPK SSATVSRNLN RFSTFVKSGG
   241  EAFVLGEASG FVKDGDKLCV VLGPYGPEWQ ENPYPFQCTI DDPTKQTKFK GMKSYISYKL
   301  VPTHTQVPVH RRYKHFDWLY ARLAEKFPVI SVPHLPEKQA TGRFEEDFIS KRRKGLIWWM
   361  NHMASHPVLA QCDVFQHFLT CPSSTDEKAW KQGKRKAEKD EMVGANFFLT LSTPPAAALD
   421  LQEVESKIDG FKCFTKKMDD SALQLNHTAN EFARKQVTGF KKEYQKVGQS FRGLSQAFEL
   481  DQQAFSVGLN QAIAFTGDAY DAIGELFAEQ PRQDLDPVMD LLALYQGHLA NFPDIIHVQK
   541  GKAWPLEQVI WSVLCRLKGA TLTAVPLWVS ESYSTGEEAS RDVDAWVFSL ECKLDCSTGS
   601  FLLEYLALGN EYSFSKVQRV PLMTVLSF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNX18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.46

Highest tissue expression

64 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.33

gnomAD pLI

0.96

gnomAD missense Z

1.97

DepMap mean gene effect

-0.11

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cleavage furrow formation
• endocytosis
• endosomal transport
• mitotic cytokinesis
• plasma membrane tubulation
• positive regulation of autophagosome assembly
• positive regulation of GTPase activity
• protein transport

Molecular functions

• phosphatidylinositol binding
• phosphatidylinositol-4,5-bisphosphate binding

Cellular components

• cytoplasmic side of plasma membrane
• cytoplasmic vesicle
• extracellular exosome
• plasma membrane
• recycling endosome membrane

Protein domainsUniProt · Pfam · InterPro

• SH3 domain
• Phox homology
• Sorting nexin 9 family
• Sorting nexin protein, WASP-binding domain
• AH/BAR domain superfamily
• SH3-like domain superfamily
• PX domain superfamily
• PX domain
• WASP-binding domain of Sorting nexin protein
• Variant SH3 domain
• Sorting nexin-18, SH3 domain
• SNX18, PX domain

KeywordsUniProt

• Cell cycle
• Cell division
• Cell membrane
• Cytoplasmic vesicle
• Endocytosis
• Endosome
• Lipid-binding
• Membrane
• Mitosis
• Protein transport
• SH3 domain
• Transport

InteractionsUniProt · HPA

Protein binding partners of SNX18 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• FCHSD1
• ITCH