Seroatlas · Human Serome Atlas

SRGAP2C

SLIT-ROBO Rho GTPase-activating protein 2C

Also known as: SRG2C_HUMAN, SRGAP2P1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DJJ0
Gene: SRGAP2C
Ensembl: ENSG00000171943
Chromosome: 1
Canonical length: 459 aa
Protein class: Predicted intracellular proteins
Subcellular location: Centrosome,Basal body,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. This human-specific locus resulted from segmental duplication of the SLIT-ROBO Rho GTPase activating protein 2B locus. The encoded protein lacks the GTPase activating protein domain compared to proteins encoded by SLIT-ROBO Rho GTPase activating protein 2, and acts antagonistically to these proteins in cortical neuron development. [provided by RefSeq, Dec 2012]

Canonical amino-acid sequenceUniProt

459 residues, UniProt reviewed canonical sequence.

>P0DJJ0|SRGAP2C
     1  MTSPAKFKKD KEIIAEYDTQ VKEIRAQLTE QMKCLDQQCE LRVQLLQDLQ DFFRKKAEIE
    61  MDYSRNLEKL AEHFLAKTRS TKDQQFKKDQ NVLSPVNCWN LLLNQVKWES RDHTTLSDIY
   121  LNNIIPRFVQ VSEDSGRLFK KSKEVGQQLQ DDLMKVLNEL YSVMKTYHMY NADSISAQSK
   181  LKEAEKQEEK QIGKSVKQED RQTPCSPDST ANVRIEEKHV RRSSVKKIEK MKEKHQAKYT
   241  ENKLKAIKAQ NEYLLALEAT NASVFKYYIH DLSDLIDQCC DLGYHASLNR ALRTFLSAEL
   301  NLEQSKHEGL DAIENAVENL DATSDKQRLM EMYNNVFCPP MKFEFQPHMG DMASQLCAQQ
   361  PVQSELVQRC QQLQSRLSTL KIENEEVKKT MEATLQTIQD IVTVEDFDVS DCFQYSNSME
   421  SVKSTVSETF MSKPSIAKRR ANQQETEQFY FTVRECYGF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SRGAP2C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 34 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 34 nTPM
spinal cord: 17 nTPM
skin: 15 nTPM
parathyroid gland: 13 nTPM
hippocampal formation: 10 nTPM
spleen: 9.8 nTPM

Single-cell type

podocytes: 746 nCPM
macrophages: 102 nCPM
kupffer cells: 83 nCPM
cdc: 71 nCPM
mesothelial cells: 70 nCPM
lymphatic endothelial cells: 64 nCPM

Immune cell

non-classical monocyte: 4.6 nTPM
classical monocyte: 3 nTPM
neutrophil: 2.8 nTPM
intermediate monocyte: 2.3 nTPM
myeloid DC: 2.2 nTPM
plasmacytoid DC: 2.1 nTPM

Brain region

cerebellum: 75 nTPM
white matter: 52 nTPM
pons: 47 nTPM
spinal cord: 45 nTPM
medulla oblongata: 44 nTPM
cerebral cortex: 38 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SRGAP2C as an antibody target. Whether an autoantibody or antibody against SRGAP2C could matter depends on whether native SRGAP2C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SRGAP2C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SRGAP2C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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