Seroatlas · Human Serome Atlas

GAS7

Growth arrest-specific protein 7

Also known as: GAS7_HUMAN, KIAA0394, MGC1348

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O60861
Gene
GAS7
Ensembl
ENSG00000007237
Chromosome
17
Canonical length
476 aa
Protein class
Cancer-related genes, Disease related genes, Predicted intracellular proteins
Subcellular location
Plasma membrane,Actin filaments,Focal adhesion sites

OverviewNCBI Gene

Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript variants encoding proteins which vary in the N-terminus have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

476 residues, UniProt reviewed canonical sequence.

>O60861|GAS7
     1  MSGARCRTLY PFSGERHGQG LRFAAGELIT LLQVPDGGWW EGEKEDGLRG WFPASYVQLL
    61  EKPGMVPPPP GEESQTVILP PGWQSYLSPQ GRRYYVNTTT NETTWERPSS SPGIPASPGS
   121  HRSSLPPTVN GYHASGTPAH PPETAHMSVR KSTGDSQNLG SSSPSKKQSK ENTITINCVT
   181  FPHPDTMPEQ QLLKPTEWSY CDYFWADKKD PQGNGTVAGF ELLLQKQLKG KQMQKEMSEF
   241  IRERIKIEED YAKNLAKLSQ NSLASQEEGS LGEAWAQVKK SLADEAEVHL KFSAKLHSEV
   301  EKPLMNFREN FKKDMKKCDH HIADLRKQLA SRYASVEKAR KALTERQRDL EMKTQQLEIK
   361  LSNKTEEDIK KARRKSTQAG DDLMRCVDLY NQAQSKWFEE MVTTTLELER LEVERVEMIR
   421  QHLCQYTQLR HETDMFNQST VEPVDQLLRK VDPAKDRELW VREHKTGNIR PVDMEI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GAS7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
176 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 176 nTPM
  • cerebral cortex: 87 nTPM
  • spinal cord: 85 nTPM
  • basal ganglia: 82 nTPM
  • hippocampal formation: 56 nTPM
  • midbrain: 53 nTPM

Single-cell type

  • neutrophils: 740 nCPM
  • fibro-adipogenic progenitors: 699 nCPM
  • monocytes: 604 nCPM
  • schwann cells: 526 nCPM
  • macrophages: 385 nCPM
  • cdc: 350 nCPM

Immune cell

  • classical monocyte: 26 nTPM
  • eosinophil: 17 nTPM
  • neutrophil: 17 nTPM
  • total PBMC: 7.7 nTPM
  • intermediate monocyte: 6.9 nTPM
  • myeloid DC: 5.3 nTPM

Brain region

  • white matter: 285 nTPM
  • cerebral cortex: 283 nTPM
  • cerebellum: 274 nTPM
  • basal ganglia: 259 nTPM
  • thalamus: 169 nTPM
  • midbrain: 168 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GAS7.

Disease | ImmuneIEDB

Conditions an epitope on GAS7 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.36
gnomAD pLI
0.85
gnomAD missense Z
2.33
DepMap mean gene effect
-0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GAS7 as an antibody target. Whether an autoantibody or antibody against GAS7 could matter depends on whether native GAS7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GAS7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GAS7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GAS7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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