Seroatlas · Human Serome Atlas

ARHGAP44

Rho GTPase-activating protein 44

Also known as: KIAA0672, RHG44_HUMAN, RICH-2, RICH2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q17R89
Gene
ARHGAP44
Ensembl
ENSG00000006740
Chromosome
17
Canonical length
818 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Enables phospholipid binding activity. Predicted to be involved in negative regulation of Rac protein signal transduction; regulation of actin cytoskeleton organization; and regulation of plasma membrane bounded cell projection organization. Located in leading edge membrane. Implicated in acquired immunodeficiency syndrome and skin melanoma. Biomarker of hepatocellular carcinoma and lung carcinoma. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

818 residues, UniProt reviewed canonical sequence.

>Q17R89|ARHGAP44
     1  MKKQFNRMRQ LANQTVGRAE KTEVLSEDLL QVEKRLELVK QVSHSTHKKL TACLQGQQGA
    61  EADKRSKKLP LTTLAQCLME GSAILGDDTL LGKMLKLCGE TEDKLAQELI HFELQVERDV
   121  IEPLFLLAEV EIPNIQKQRK HLAKLVLDMD SSRTRWQQTS KSSGLSSSLQ PAGAKADALR
   181  EEMEEAANRV EICRDQLSAD MYSFVAKEID YANYFQTLIE VQAEYHRKSL TLLQAVLPQI
   241  KAQQEAWVEK PSFGKPLEEH LTISGREIAF PIEACVTMLL ECGMQEEGLF RVAPSASKLK
   301  KLKAALDCCV VDVQEYSADP HAIAGALKSY LRELPEPLMT FELYDEWIQA SNVQEQDKKL
   361  QALWNACEKL PKANHNNIRY LIKFLSKLSE YQDVNKMTPS NMAIVLGPNL LWPQAEGNIT
   421  EMMTTVSLQI VGIIEPIIQH ADWFFPGEIE FNITGNYGSP VHVNHNANYS SMPSPDMDPA
   481  DRRQPEQARR PLSVATDNMM LEFYKKDGLR KIQSMGVRVM DTNWVARRGS SAGRKVSCAP
   541  PSMQPPAPPA ELAAPLPSPL PEQPLDSPAA PALSPSGLGL QPGPERTSTT KSKELSPGSA
   601  QKGSPGSSQG TACAGTQPGA QPGAQPGASP SPSQPPADQS PHTLRKVSKK LAPIPPKVPF
   661  GQPGAMADQS AGQPSPVSLS PTPPSTPSPY GLSYPQGYSL ASGQLSPAAA PPLASPSVFT
   721  STLSKSRPTP KPRQRPTLPP PQPPTVNLSA SSPQSTEAPM LDGMSPGESM STDLVHFDIP
   781  SIHIELGSTL RLSPLEHMRR HSVTDKRDSE EESESTAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARHGAP44 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
24 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 24 nTPM
  • cerebral cortex: 22 nTPM
  • hippocampal formation: 17 nTPM
  • basal ganglia: 17 nTPM
  • parathyroid gland: 16 nTPM
  • colon: 14 nTPM

Single-cell type

  • retinal horizontal cells: 1,130 nCPM
  • thyrotrophs: 553 nCPM
  • retinal amacrine cells: 442 nCPM
  • lactotrophs: 435 nCPM
  • mesothelial cells: 417 nCPM
  • brain excitatory neurons: 323 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 125 nTPM
  • hippocampal formation: 91 nTPM
  • white matter: 90 nTPM
  • thalamus: 82 nTPM
  • amygdala: 81 nTPM
  • pons: 76 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.22
gnomAD pLI
1
gnomAD missense Z
2.39
DepMap mean gene effect
0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARHGAP44 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARHGAP44 as an antibody target. Whether an autoantibody or antibody against ARHGAP44 could matter depends on whether native ARHGAP44 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARHGAP44 is annotated at the cell surface, where native ARHGAP44 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ARHGAP44 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARHGAP44. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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