Seroatlas · Human Serome Atlas

ASAP3

Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3

Also known as: ASAP3_HUMAN, CENTB6, DDEFL1, FLJ20199, UPLC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TDY4
Gene
ASAP3
Ensembl
ENSG00000088280
Chromosome
1
Canonical length
903 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles

OverviewNCBI Gene

This gene encodes a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain additional ankyrin repeat and pleckstrin homology domains. The Arf GAP domain of this protein catalyzes the hydrolysis of GTP bound to Arf proteins. The encoded protein promotes cell differentiation and migration and has been implicated in cancer cell invasion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]

Canonical amino-acid sequenceUniProt

903 residues, UniProt reviewed canonical sequence.

>Q8TDY4|ASAP3
     1  MPEQFSVAEF LAVTAEDLSS PAGAAAFAAK MPRYRGAALA REEILEGDQA ILQRIKKAVR
    61  AIHSSGLGHV ENEEQYREAV ESLGNSHLSQ NSHELSTGFL NLAVFTREVA ALFKNLIQNL
   121  NNIVSFPLDS LMKGQLRDGR QDSKKQLEKA WKDYEAKMAK LEKERDRARV TGGIPGEVAQ
   181  DMQRERRIFQ LHMCEYLLKA GESQMKQGPD FLQSLIKFFH AQHNFFQDGW KAAQSLFPFI
   241  EKLAASVHAL HQAQEDELQK LTQLRDSLRG TLQLESREEH LSRKNSGCGY SIHQHQGNKQ
   301  FGTEKVGFLY KKSDGIRRVW QKRKCGVKYG CLTISHSTIN RPPVKLTLLT CQVRPNPEEK
   361  KCFDLVTHNR TYHFQAEDEH ECEAWVSVLQ NSKDEALSSA FLGEPSAGPG SWGSAGHDGE
   421  PHDLTKLLIA EVKSRPGNSQ CCDCGAADPT WLSTNLGVLT CIQCSGVHRE LGVRFSRMQS
   481  LTLDLLGPSE LLLALNMGNT SFNEVMEAQL PSHGGPKPSA ESDMGTRRDY IMAKYVEHRF
   541  ARRCTPEPQR LWTAICNRDL LSVLEAFANG QDFGQPLPGP DAQAPEELVL HLAVKVANQA
   601  SLPLVDFIIQ NGGHLDAKAA DGNTALHYAA LYNQPDCLKL LLKGRALVGT VNEAGETALD
   661  IARKKHHKEC EELLEQAQAG TFAFPLHVDY SWVISTEPGS DSEEDEEEKR CLLKLPAQAH
   721  WASGRLDISN KTYETVASLG AATPQGESED CPPPLPVKNS SRTLVQGCAR HASGDRSEVS
   781  SLSSEAPETP ESLGSPASSS SLMSPLEPGD PSQAPPNSEE GLREPPGTSR PSLTSGTTPS
   841  EMYLPVRFSS ESTRSYRRGA RSPEDGPSAR QPLPRRNVPV GITEGDGSRT GSLPASSVQL
   901  LQD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ASAP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
56 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 56 nTPM
  • skin: 50 nTPM
  • skeletal muscle: 41 nTPM
  • adrenal gland: 37 nTPM
  • salivary gland: 36 nTPM
  • vagina: 32 nTPM

Single-cell type

  • distal convoluted tubule cells: 63 nCPM
  • astrocytes: 62 nCPM
  • choroid plexus epithelial cells: 61 nCPM
  • renal connecting tubule cells: 51 nCPM
  • proximal tubule cells: 43 nCPM
  • renal collecting duct intercalated cells: 41 nCPM

Immune cell

  • non-classical monocyte: 0.2 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • medulla oblongata: 16 nTPM
  • thalamus: 14 nTPM
  • pons: 14 nTPM
  • midbrain: 13 nTPM
  • spinal cord: 13 nTPM
  • cerebellum: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.71
gnomAD pLI
0
gnomAD missense Z
1.36
DepMap mean gene effect
-0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ASAP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ASAP3 as an antibody target. Whether an autoantibody or antibody against ASAP3 could matter depends on whether native ASAP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ASAP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ASAP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ASAP3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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