Seroatlas · Human Serome Atlas

FCHSD2

F-BAR and double SH3 domains protein 2

Also known as: FCSD2_HUMAN, KIAA0769, SH3MD3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O94868
Gene: FCHSD2
Ensembl: ENSG00000137478
Chromosome: 11
Canonical length: 740 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles,Plasma membrane,Actin filaments,Focal adhesion sites
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables phosphatidylinositol-3,4,5-trisphosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in clathrin-dependent endocytosis and positive regulation of Arp2/3 complex-mediated actin nucleation. Located in clathrin-coated pit and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

740 residues, UniProt reviewed canonical sequence.

>O94868|FCHSD2
     1  MQPPPRKVKV TQELKNIQVE QMTKLQAKHQ AECDLLEDMR TFSQKKAAIE REYAQGMQKL
    61  ASQYLKRDWP GVKADDRNDY RSMYPVWKSF LEGTMQVAQS RMNICENYKN FISEPARTVR
   121  SLKEQQLKRC VDQLTKIQTE LQETVKDLAK GKKKYFETEQ MAHAVREKAD IEAKSKLSLF
   181  QSRISLQKAS VKLKARRSEC NSKATHARND YLLTLAAANA HQDRYYQTDL VNIMKALDGN
   241  VYDHLKDYLI AFSRTELETC QAVQNTFQFL LENSSKVVRD YNLQLFLQEN AVFHKPQPFQ
   301  FQPCDSDTSR QLESETGTTE EHSLNKEARK WATRVAREHK NIVHQQRVLN DLECHGAAVS
   361  EQSRAELEQK IDEARENIRK AEIIKLKAEA RLDLLKQIGV SVDTWLKSAM NQVMEELENE
   421  RWARPPAVTS NGTLHSLNAD TEREEGEEFE DNMDVFDDSS SSPSGTLRNY PLTCKVVYSY
   481  KASQPDELTI EEHEVLEVIE DGDMEDWVKA RNKVGQVGYV PEKYLQFPTS NSLLSMLQSL
   541  AALDSRSHTS SNSTEAELVS GSLNGDASVC FVKALYDYEG QTDDELSFPE GAIIRILNKE
   601  NQDDDGFWEG EFNGRIGVFP SVLVEELSAS ENGDTPWMRE IQISPSPKPH ASLPPLPLYD
   661  QPPSSPYPSP DKRSSLYFPR SPSANEKSLH AESPGFSQAS RHTPETSYGK LRPVRAAPPP
   721  PTQNHRRPAE KIEDVEITLV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FCHSD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

tonsil: 43 nTPM
lymph node: 42 nTPM
blood vessel: 41 nTPM
spleen: 40 nTPM
appendix: 32 nTPM
placenta: 29 nTPM

Single-cell type

pdcs: 2,335 nCPM
b-cells: 1,233 nCPM
microglia: 1,168 nCPM
neutrophils: 884 nCPM
sertoli cells: 776 nCPM
thymocytes: 763 nCPM

Immune cell

plasmacytoid DC: 32 nTPM
naive B-cell: 27 nTPM
memory B-cell: 22 nTPM
neutrophil: 20 nTPM
eosinophil: 19 nTPM
basophil: 18 nTPM

Brain region

basal ganglia: 89 nTPM
white matter: 84 nTPM
hypothalamus: 83 nTPM
amygdala: 82 nTPM
cerebral cortex: 78 nTPM
thalamus: 77 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.37
gnomAD pLI: 0.57
gnomAD missense Z: 1.84
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

FCH domain
SH3 domain
AH/BAR domain superfamily
F-BAR domain
FCHSD, SH3 domain 1
SH3-like domain superfamily
SH3 domain
Fes/CIP4, and EFC/F-BAR homology domain
Variant SH3 domain
F-BAR and double SH3 domains protein 2, F-BAR domain
FCHSD2, SH3 domain 2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FCHSD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FCHSD2 as an antibody target. Whether an autoantibody or antibody against FCHSD2 could matter depends on whether native FCHSD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FCHSD2 is annotated at the cell surface, where native FCHSD2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FCHSD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...