Seroatlas · Human Serome Atlas

SNX33

Sorting nexin-33

Also known as: MGC32065, SH3PX3, SH3PXD3C, SNX30, SNX33_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WV41
Gene: SNX33
Ensembl: ENSG00000173548
Chromosome: 15
Canonical length: 574 aa
Protein class: Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is involved in cytoskeletal reorganization, vesicle trafficking, endocytosis, and mitosis. The encoded protein is essential for the creation of the cleavage furrow during mitosis and for completion of mitosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

574 residues, UniProt reviewed canonical sequence.

>Q8WV41|SNX33
     1  MALKGRALYD FHSENKEEIS IQQDEDLVIF SETSLDGWLQ GQNSRGETGL FPASYVEIVR
    61  SGISTNHADY SSSPAGSPGA QVSLYNSPSV ASPARSGGGS GFLSNQGSFE EDDDDDWDDW
   121  DDGCTVVEEP RAGGLGTNGH PPLNLSYPGA YPSQHMAFRP KPPLERQDSL ASAKRGSVVG
   181  RNLNRFSCFV RSGVEAFILG DVPMMAKIAE TYSIEMGPRG PQWKANPHPF ACSVEDPTKQ
   241  TKFKGIKSYI SYKLTPTHAA SPVYRRYKHF DWLYNRLLHK FTVISVPHLP EKQATGRFEE
   301  DFIEKRKRRL ILWMDHMTSH PVLSQYEGFQ HFLSCLDDKQ WKMGKRRAEK DEMVGASFLL
   361  TFQIPTEHQD LQDVEDRVDT FKAFSKKMDD SVLQLSTVAS ELVRKHVGGF RKEFQKLGSA
   421  FQAISHSFQM DPPFCSEALN SAISHTGRTY EAIGEMFAEQ PKNDLFQMLD TLSLYQGLLS
   481  NFPDIIHLQK GAFAKVKESQ RMSDEGRMVQ DEADGIRRRC RVVGFALQAE MNHFHQRREL
   541  DFKHMMQNYL RQQILFYQRV GQQLEKTLRM YDNL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNX33 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 41 nTPM

Expression across tissuesHPA

Tissue

esophagus: 41 nTPM
blood vessel: 35 nTPM
vagina: 30 nTPM
cervix: 29 nTPM
skin: 28 nTPM
liver: 27 nTPM

Single-cell type

esophageal apical cells: 123 nCPM
pancreatic acinar cells: 30 nCPM
alveolar cells type 1: 24 nCPM
foveolar cells: 22 nCPM
epicardial cells: 21 nCPM
smooth muscle cells: 19 nCPM

Immune cell

classical monocyte: 0.5 nTPM
myeloid DC: 0.4 nTPM
memory CD4 T-cell: 0.3 nTPM
gdT-cell: 0.2 nTPM
MAIT T-cell: 0.2 nTPM
T-reg: 0.2 nTPM

Brain region

medulla oblongata: 22 nTPM
thalamus: 19 nTPM
choroid plexus: 17 nTPM
amygdala: 15 nTPM
basal ganglia: 15 nTPM
midbrain: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.61
gnomAD pLI: 0.08
gnomAD missense Z: 1.79
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNX33 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNX33 as an antibody target. Whether an autoantibody or antibody against SNX33 could matter depends on whether native SNX33 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNX33 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNX33 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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