Seroatlas · Human Serome Atlas

FER

Tyrosine-protein kinase Fer

Also known as: FER_HUMAN, PPP1R74, TYK3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P16591
Gene
FER
Ensembl
ENSG00000151422
Chromosome
5
Canonical length
822 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Cytosol
Quaternary structure
Homotrimer

OverviewNCBI Gene

The protein encoded by this gene is a member of the FPS/FES family of non-transmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Apr 2015]

Canonical amino-acid sequenceUniProt

822 residues, UniProt reviewed canonical sequence.

>P16591|FER
     1  MGFGSDLKNS HEAVLKLQDW ELRLLETVKK FMALRIKSDK EYASTLQNLC NQVDKESTVQ
    61  MNYVSNVSKS WLLMIQQTEQ LSRIMKTHAE DLNSGPLHRL TMMIKDKQQV KKSYIGVHQQ
   121  IEAEMIKVTK TELEKLKCSY RQLIKEMNSA KEKYKEALAK GKETEKAKER YDKATMKLHM
   181  LHNQYVLALK GAQLHQNQYY DITLPLLLDS LQKMQEEMIK ALKGIFDEYS QITSLVTEEI
   241  VNVHKEIQMS VEQIDPSTEY NNFIDVHRTT AAKEQEIEFD TSLLEENENL QANEIMWNNL
   301  TAESLQVMLK TLAEELMQTQ QMLLNKEEAV LELEKRIEES SETCEKKSDI VLLLSQKQAL
   361  EELKQSVQQL RCTEAKFSAQ KELLEQKVQE NDGKEPPPVV NYEEDARSVT SMERKERLSK
   421  FESIRHSIAG IIRSPKSALG SSALSDMISI SEKPLAEQDW YHGAIPRIEA QELLKKQGDF
   481  LVRESHGKPG EYVLSVYSDG QRRHFIIQYV DNMYRFEGTG FSNIPQLIDH HYTTKQVITK
   541  KSGVVLLNPI PKDKKWILSH EDVILGELLG KGNFGEVYKG TLKDKTSVAV KTCKEDLPQE
   601  LKIKFLQEAK ILKQYDHPNI VKLIGVCTQR QPVYIIMELV SGGDFLTFLR RKKDELKLKQ
   661  LVKFSLDAAA GMLYLESKNC IHRDLAARNC LVGENNVLKI SDFGMSRQED GGVYSSSGLK
   721  QIPIKWTAPE ALNYGRYSSE SDVWSFGILL WETFSLGVCP YPGMTNQQAR EQVERGYRMS
   781  APQHCPEDIS KIMMKCWDYK PENRPKFSEL QKELTIIKRK LT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FER can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
8.8 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 8.8 nTPM
  • testis: 6.1 nTPM
  • retina: 5.2 nTPM
  • thyroid gland: 5 nTPM
  • skin: 4.3 nTPM
  • blood vessel: 4.2 nTPM

Single-cell type

  • mast cells: 2,092 nCPM
  • sertoli cells: 834 nCPM
  • microglia: 558 nCPM
  • fibro-adipogenic progenitors: 543 nCPM
  • renal collecting duct principal cells: 525 nCPM
  • pituitary stem cells: 499 nCPM

Immune cell

  • basophil: 1.3 nTPM
  • gdT-cell: 0.5 nTPM
  • MAIT T-cell: 0.5 nTPM
  • myeloid DC: 0.3 nTPM
  • non-classical monocyte: 0.3 nTPM
  • classical monocyte: 0.2 nTPM

Brain region

  • white matter: 16 nTPM
  • spinal cord: 14 nTPM
  • hypothalamus: 14 nTPM
  • medulla oblongata: 14 nTPM
  • midbrain: 13 nTPM
  • amygdala: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.36
gnomAD pLI
0.66
gnomAD missense Z
1.26
DepMap mean gene effect
0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FER in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FER as an antibody target. Whether an autoantibody or antibody against FER could matter depends on whether native FER is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FER is annotated at the cell surface, where native FER is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FER as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FER. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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