Seroatlas · Human Serome Atlas

SH3GLB1

Endophilin-B1

Also known as: Bif-1, CGI-61, KIAA0491, PPP1R70, SHLB1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y371
Gene
SH3GLB1
Ensembl
ENSG00000097033
Chromosome
1
Canonical length
365 aa
Protein class
Metabolic proteins, Predicted intracellular proteins, Transporters
Subcellular location
Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a SRC homology 3 domain-containing protein. The encoded protein interacts with the proapoptotic member of the Bcl-2 family, Bcl-2-associated X protein (Bax) and may be involved in regulating apoptotic signaling pathways. This protein may also be involved in maintaining mitochondrial morphology. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

365 residues, UniProt reviewed canonical sequence.

>Q9Y371|SH3GLB1
     1  MNIMDFNVKK LAADAGTFLS RAVQFTEEKL GQAEKTELDA HLENLLSKAE CTKIWTEKIM
    61  KQTEVLLQPN PNARIEEFVY EKLDRKAPSR INNPELLGQY MIDAGTEFGP GTAYGNALIK
   121  CGETQKRIGT ADRELIQTSA LNFLTPLRNF IEGDYKTIAK ERKLLQNKRL DLDAAKTRLK
   181  KAKAAETRNS SEQELRITQS EFDRQAEITR LLLEGISSTH AHHLRCLNDF VEAQMTYYAQ
   241  CYQYMLDLQK QLGSFPSNYL SNNNQTSVTP VPSVLPNAIG SSAMASTSGL VITSPSNLSD
   301  LKECSGSRKA RVLYDYDAAN STELSLLADE VITVFSVVGM DSDWLMGERG NQKGKVPITY
   361  LELLN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SH3GLB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
163 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 163 nTPM
  • testis: 102 nTPM
  • adipose tissue: 100 nTPM
  • tongue: 92 nTPM
  • esophagus: 74 nTPM
  • heart muscle: 68 nTPM

Single-cell type

  • neutrophils: 1,166 nCPM
  • esophageal apical cells: 1,112 nCPM
  • late primary spermatocytes: 954 nCPM
  • early spermatids: 578 nCPM
  • esophageal suprabasal cells: 388 nCPM
  • extravillous trophoblasts: 311 nCPM

Immune cell

  • neutrophil: 303 nTPM
  • basophil: 154 nTPM
  • non-classical monocyte: 77 nTPM
  • eosinophil: 67 nTPM
  • T-reg: 66 nTPM
  • intermediate monocyte: 65 nTPM

Brain region

  • white matter: 59 nTPM
  • medulla oblongata: 56 nTPM
  • hypothalamus: 52 nTPM
  • spinal cord: 50 nTPM
  • basal ganglia: 48 nTPM
  • thalamus: 47 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.24
gnomAD pLI
0.99
gnomAD missense Z
1.63
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SH3GLB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SH3GLB1 as an antibody target. Whether an autoantibody or antibody against SH3GLB1 could matter depends on whether native SH3GLB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SH3GLB1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SH3GLB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SH3GLB1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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