Seroatlas · Human Serome Atlas

PICK1

PRKCA-binding protein

Also known as: dJ1039K5, MGC15204, PICK1_HUMAN, PRKCABP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NRD5
Gene
PICK1
Ensembl
ENSG00000100151
Chromosome
22
Canonical length
415 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

415 residues, UniProt reviewed canonical sequence.

>Q9NRD5|PICK1
     1  MFADLDYDIE EDKLGIPTVP GKVTLQKDAQ NLIGISIGGG AQYCPCLYIV QVFDNTPAAL
    61  DGTVAAGDEI TGVNGRSIKG KTKVEVAKMI QEVKGEVTIH YNKLQADPKQ GMSLDIVLKK
   121  VKHRLVENMS SGTADALGLS RAILCNDGLV KRLEELERTA ELYKGMTEHT KNLLRAFYEL
   181  SQTHRAFGDV FSVIGVREPQ PAASEAFVKF ADAHRSIEKF GIRLLKTIKP MLTDLNTYLN
   241  KAIPDTRLTI KKYLDVKFEY LSYCLKVKEM DDEEYSCIAL GEPLYRVSTG NYEYRLILRC
   301  RQEARARFSQ MRKDVLEKME LLDQKHVQDI VFQLQRLVST MSKYYNDCYA VLRDADVFPI
   361  EVDLAHTTLA YGLNQEEFTD GEEEEEEEDT AAGEPSRDTR GAAGPLDKGG SWCDS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PICK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • parathyroid gland: 28 nTPM
  • pituitary gland: 28 nTPM
  • testis: 26 nTPM
  • skeletal muscle: 25 nTPM
  • prostate: 25 nTPM
  • cerebral cortex: 24 nTPM

Single-cell type

  • early spermatids: 137 nCPM
  • late spermatids: 126 nCPM
  • breast lactating cells: 57 nCPM
  • late primary spermatocytes: 49 nCPM
  • kupffer cells: 48 nCPM
  • syncytiotrophoblasts: 47 nCPM

Immune cell

  • myeloid DC: 1.6 nTPM
  • naive B-cell: 1.1 nTPM
  • memory CD8 T-cell: 1 nTPM
  • naive CD4 T-cell: 1 nTPM
  • classical monocyte: 0.9 nTPM
  • T-reg: 0.7 nTPM

Brain region

  • white matter: 39 nTPM
  • cerebral cortex: 29 nTPM
  • pons: 27 nTPM
  • thalamus: 25 nTPM
  • basal ganglia: 23 nTPM
  • medulla oblongata: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.67
gnomAD pLI
0.01
gnomAD missense Z
2.01
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PICK1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PICK1 as an antibody target. Whether an autoantibody or antibody against PICK1 could matter depends on whether native PICK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PICK1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PICK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PICK1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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