Seroatlas · Human Serome Atlas

SNX8

Sorting nexin-8

Also known as: Mvp1, SNX8_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y5X2
Gene
SNX8
Ensembl
ENSG00000106266
Chromosome
7
Canonical length
465 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles

OverviewNCBI Gene

Enables identical protein binding activity and phosphatidylinositol binding activity. Involved in early endosome to Golgi transport and intracellular protein transport. Located in early endosome membrane and retromer complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

465 residues, UniProt reviewed canonical sequence.

>Q9Y5X2|SNX8
     1  MTGRAMDPLP AAAVGAAAEA EADEEADPPA SDLPTPQAIE PQAIVQQVPA PSRMQMPQGN
    61  PLLLSHTLQE LLARDTVQVE LIPEKKGLFL KHVEYEVSSQ RFKSSVYRRY NDFVVFQEML
   121  LHKFPYRMVP ALPPKRMLGA DREFIEARRR ALKRFVNLVA RHPLFSEDVV LKLFLSFSGS
   181  DVQNKLKESA QCVGDEFLNC KLATRAKDFL PADIQAQFAI SRELIRNIYN SFHKLRDRAE
   241  RIASRAIDNA ADLLIFGKEL SAIGSDTTPL PSWAALNSST WGSLKQALKG LSVEFALLAD
   301  KAAQQGKQEE NDVVEKLNLF LDLLQSYKDL CERHEKGVLH KHQRALHKYS LMKRQMMSAT
   361  AQNREPESVE QLESRIVEQE NAIQTMELRN YFSLYCLHQE TQLIHVYLPL TSHILRAFVN
   421  SQIQGHKEMS KVWNDLRPKL SCLFAGPHST LTPPCSPPED GLCPH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNX8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
30 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 30 nTPM
  • testis: 22 nTPM
  • lymph node: 20 nTPM
  • tonsil: 17 nTPM
  • spinal cord: 16 nTPM
  • adipose tissue: 14 nTPM

Single-cell type

  • late spermatids: 486 nCPM
  • hofbauer cells: 215 nCPM
  • cdc: 176 nCPM
  • macrophages: 153 nCPM
  • esophageal apical cells: 131 nCPM
  • retinal horizontal cells: 128 nCPM

Immune cell

  • naive B-cell: 31 nTPM
  • memory B-cell: 26 nTPM
  • myeloid DC: 22 nTPM
  • non-classical monocyte: 18 nTPM
  • intermediate monocyte: 17 nTPM
  • classical monocyte: 15 nTPM

Brain region

  • thalamus: 34 nTPM
  • medulla oblongata: 33 nTPM
  • white matter: 32 nTPM
  • basal ganglia: 31 nTPM
  • amygdala: 30 nTPM
  • cerebral cortex: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.57
gnomAD pLI
0.06
gnomAD missense Z
0.28
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNX8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNX8 as an antibody target. Whether an autoantibody or antibody against SNX8 could matter depends on whether native SNX8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNX8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNX8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SNX8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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