Seroatlas · Human Serome Atlas

ARHGEF37

Rho guanine nucleotide exchange factor 37

Also known as: ARH37_HUMAN, FLJ41603

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A1IGU5
Gene
ARHGEF37
Ensembl
ENSG00000183111
Chromosome
5
Canonical length
675 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

675 residues, UniProt reviewed canonical sequence.

>A1IGU5|ARHGEF37
     1  MAKHGADEPS SRSGSPDREG RASEDRSLLH QRLAVRELID TEVSYLHMLQ LCASDIRSRL
    61  QQLPQGDLDV LFSNIDDIIK VNSRFLHDLQ ETASKEEEQV QLVGNIFLEF QEELEQVYKV
   121  YCASYDQALL LVDTYRKEPE LQRHIQGIVE AVVPQAGSSG LSFLLVIPLQ RITRYPLLLQ
   181  KILENTVPDA SAYPVLQRAV SALQDVNTNI NEYKMRKEVA SKYTKVEQLT LRERLARINT
   241  HTLSKKTTRL SQLLKQEAGL IPRTEDKEFD DLEERFQWVS LCVTELKNNV AAYLDNLQAF
   301  LYFRPHEYNL DIPEGPAVQY CNLARDLHLE AFLKFKQRLE GLVWQPLCSL AKALLGPQNL
   361  IKKRLDKLLD FERVEEKLLE VGSVTYQEEA ARHTYQALNS LLVAELPQFN QLVMQWLGQI
   421  MCTFVTLQRD LAKQVLQRAE GSMAQLPHHH VPEPAFRKLV EDALGRTSNQ LRSFQETFEK
   481  VQPPPTTQPL LPGSERQVQA LLSRYGPGKL YQVTSNISGT GTLDLTLPRG QIVAILQNKD
   541  TKGNSGRWLV DTGGHRGYVP AGKLQLYHVV PSAEELRRQA GLNKDPRCLT PEPSPALVPS
   601  IPTMNQVIAA YPFVARSSHE VSLQAGQPVT ILEAQDKKGN PEWSLVEVNG QRGYVPSGFL
   661  ARARSPVLWG WSLPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARHGEF37 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
58 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 58 nTPM
  • skin: 43 nTPM
  • salivary gland: 38 nTPM
  • choroid plexus: 34 nTPM
  • seminal vesicle: 33 nTPM
  • midbrain: 33 nTPM

Single-cell type

  • prostatic glandular cells: 120 nCPM
  • podocytes: 119 nCPM
  • müller glia: 111 nCPM
  • salivary acinar cells: 97 nCPM
  • lacrimal acinar cells: 94 nCPM
  • oligodendrocytes: 91 nCPM

Immune cell

  • basophil: 9.3 nTPM
  • neutrophil: 3.1 nTPM
  • intermediate monocyte: 0.8 nTPM
  • plasmacytoid DC: 0.7 nTPM
  • classical monocyte: 0.5 nTPM
  • naive CD4 T-cell: 0.5 nTPM

Brain region

  • white matter: 80 nTPM
  • medulla oblongata: 63 nTPM
  • basal ganglia: 56 nTPM
  • midbrain: 51 nTPM
  • pons: 51 nTPM
  • thalamus: 50 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.07
gnomAD pLI
0
gnomAD missense Z
0.27
DepMap mean gene effect
0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARHGEF37 as an antibody target. Whether an autoantibody or antibody against ARHGEF37 could matter depends on whether native ARHGEF37 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARHGEF37 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARHGEF37 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARHGEF37. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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